| HPLC法测定风痛安胶囊中粉防己碱和防己诺林碱的含量 |
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| 引用本文： | 傅黎春,李桃英,刘映.HPLC法测定风痛安胶囊中粉防己碱和防己诺林碱的含量[J].中国药事,2009,23(4):365-367. |
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| 作者姓名： | 傅黎春 李桃英 刘映 |
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| 作者单位： | 湖南省衡阳市药品检验所,衡阳,421001 |
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| 摘 要： | 目的建立风痛安胶囊中粉防己碱和防己诺林碱含量的测定方法。方法采用高效液相色谱法。色谱柱为Diamonsil C18;流动相：甲醇-乙腈-0.03mol·L^-1磷酸二氢钾溶液-二乙胺（55∶25∶20∶0.05）;检测波长230nm。结果粉防己碱、防己诺林碱进样量分别在0.1355～2.7100μg（r=0.9999）,0.1033～2.0660μg（r=0.9999）范围内线性关系良好。粉防己碱、防己诺林碱平均回收率分别为98.02%（RSD=1.31%）,97.11%（RSD=1.42%）。结论本方法简便,专属,重复性好,可用于该制剂的质量控制。
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| 关 键 词： | 风痛安胶囊 粉防己碱 防己诺林碱 HPLC |
Determination of Tetrandrine and Fangchinoline in Fengtongan Capsules by HPLC |
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| Fu Lichun,Li Taoying,Liu Ying.Determination of Tetrandrine and Fangchinoline in Fengtongan Capsules by HPLC[J].Chinese Pharmaceutical Affairs,2009,23(4):365-367. |
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| Authors: | Fu Lichun Li Taoying Liu Ying |
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| Institution: | (Hengyang Institute for Drug Control, Hunan province, Hengyang 421001) |
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| Abstract: | Objective To develop a method for determination of tetrandrine and fangchinoline in Fengtongan Capsules. Methods Using RP-HPLC method with Diamonsil C18 column, the mobile phase was a mixture of methanol-acetonitrile-0.03mol ·L^-1 potassium dihydrogen phosphate-diethylamine （55 ： 25 ： 20 ： 0.05）, the detection wavelength was 230nm. Results There was a good linear relationship when the content of tetrandrine was 0. 1355-2. 7100μg, and fangchinoline was 0. 1033-2.0660μg. The average recovery of tetrandrine was 98.02% （RSD= 1.31%, n= 9）, and 97. 11% （RSD= 1.42%, n= 9） for fangchinoline. Conclusions The method is simple, selective and reproducible. It can be used for quality control of Fengtongan Capsules. |
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| Keywords: | HPLC |
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