TP、PTP及CAP化疗方案治疗上皮性卵巢癌的比较

目的探讨进口紫杉醇(泰素)与铂类联合化疗方案(TP)、国产紫杉醇(紫素)与铂类联合化疗方案(PIP)治疗上皮性卵巢癌的疗效及毒性,并与环磷酰氨、阿霉素及铂类方案(CAP)进行比较。方法对1993年12月至1999年4月采用TP、PIP及CAP化疗方案治疗的卵巢癌患者进行回顾性分析。泰素组(TP组)22例、紫素组(PTP组)18例,CAP组38例。结果泰素组有效率为55.6％,紫素组有效率为71.4％;紫杉醇作为一线用药有效率为88.9％,CAP作为一线用药有效率为55.9％。紫杉醇的毒副作用有造血功能抑制、消化道症状、脱发、外周神经炎、肌肉、关节疼痛,其中2例出现Ⅲ度外周神经损伤。结论TP或PTP作为一线用药疗效高于CAP,国产及进口紫杉醇在疗效及副作用上无明显差异。

Comparison of comMnation therapy with TP, PIP and CAP in patients with epithelial ovarian cardnoma

Objective To study the effect and toxicities of paclitaxel (USA) combined with platinum (TP) and paclitaxel (Chinese) combined with platinum (PTP) in the treatment of epithelial ovarian cancer, and to compare with the combination of cyclophosphamidex adriamycin and platinum ( CAP ) .Methods A retrospective analysis in the treatment of ovarian cancer with paclitaxel and CAP from December 1993 to April 1999 was done. Including 22 patients in TP group, 18 patients in PIP group and 38 patients in CAP group.Results The response rate ( RR ) in TP group was 55.6%, while the RR in FTP group was 71.4%. In first line chemotherapy, the RR in paclitaxel groups was 88.9% , but 55.9% in CAP group . Besides myelosuppres-sion, nausea, vomiting and alopecia, the main side - effects of paclitaxel were : peripheral neuritis, myalgia and arthralgia, grade 3 peripheral neuropathy were found in two patients.Conclusions Paclitaxel in combination with platinum is clinically more effective than the standard therapy with CAP in first line chemotherapy for the treatment of ovarian cancer . The results showed no apparent differences in the effect and toxicity for two kinds of paclitaxel .