基质金属蛋白酶9基因多态性与肿瘤易感性Meta分析

目的 探讨基质金属蛋白酶9 (MMP-9)基因rs3918242位点多态性与肿瘤易感性的关系.方法 使用PubMed数据库检索2011年4月以前相关文献,按纳入标准搜索研究MMP-9 rs3918242 C/T多态性与肿瘤易感性相关的文献,采用STATA软件进行统计分析.结果 共有4 124例肿瘤患者和4 728名对照个体被纳入荟萃分析.分析表明MMP-9 rs3918242 C/T多态性与整个肿瘤易感性无显著相关(等位基因比P=0.378,OR=0.94,95％ CI:0.83 ～ 1.07),但在肿瘤分层分析中发现MMP-9突变型等位基因T显著降低了肺癌(P =0.026,OR=0.70,95％ CI:0.51 ～0.96)和结直肠癌(P=0.016,OR=0.80,95％ CI:0.66 ～ 0.96)的易感性.结论 MMP-9 rs3918242 C/T多态性与结直肠癌和肺癌易感性存在一定的相关性.

MMP-9 gene polymorphism and cancer risk: a meta-analysis

  Objective  To study the correlation between MMP-9 rs3918242 C>T polymorphism and cancer risk.  Methods  PubMed database was utilized to search the relative artiles concerning association between MMP-9 rs3918242 C>T polymorphism and cancer risk (last search updated on April 2011). All the statistical analysis was performed by STATA software.  Results  4,124 cancer patients and 4,728 control subjects were included in this meta-analysis. No association was observed in the overall analysis (allelic contrast P = 0.378, OR= 0.94, 95% CI0.83-1.07). However, in the stratified analysis by cancer type, MMP-9 -1562 T allele was found to decrease the lung cancer(P =0.026, OR=0.70,95%CI0.51-0.96) and colorectal cancer(P = 0.016, OR=0.80,95%CI0.66-0.96).  Conclusion  MMP-9 rs3918242 C/T polymorphism is correlated with colorectal cancer and lung cancer.