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| 半合成新抗生素──抗生素89－07的合成和结构测定 | |
| 引用本文： | 范瑾,赵敏,刘军,胡小玲,范铭琦. 半合成新抗生素──抗生素89－07的合成和结构测定[J]. 中国抗生素杂志, 1995, 0(6) |
| 作者姓名： | 范瑾 赵敏 刘军 胡小玲 范铭琦 |
| 作者单位： | 江苏省微生物研究所 |
| 摘 要： | 以庆大霉素Ｃ１ａ为母核，采用保护合成法，将其二脱氧链霉胺（２－ＤＯＳ）１－Ｎ位上的１个氢原子用１个乙基取代，得到半合成新抗生素８９－０７。经ＩＲ、ＵＶ、ＭＳ、１Ｈ－ＮＭＲ、１３Ｃ－ＮＭＲ、ＤＥＰＴ、１Ｈ－１Ｈ－ＣＯＳＹ、１３Ｃ－１Ｈ－ＣＯＳＹ等测试证实该抗生素和中间体的结构分别与１－Ｎ－乙基ＧＭＣ１ａ和３．２’，６’－三－Ｎ－乙酰基ＧＭＣ１ａ（Ｐ１）、３，２’，６’－三－Ｎ－乙酰基－１－Ｎ－乙基ＧＭＣ１ａ（Ｐ２）相一致。 |
| 关 键 词： | 抗生素89－07；合成；结构测定 |
Synthesis and structure determination of semisynthetic antibiotic 89-07 |
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| Fan Jin,Zhao Min,Lii Jun, Hu Xiaoling, and Fan Mingqi. Synthesis and structure determination of semisynthetic antibiotic 89-07[J]. Chinese Journal of Antibiotics, 1995, 0(6) | |
| Authors: | Fan Jin Zhao Min Lii Jun Hu Xiaoling Fan Mingqi |
| Abstract: | A hydrogen atom on 1-N position of 2-deoxystreptomine of gentamicin C1a was substituted by an ethyl group by means of protective synthetic method, a newsemisynthetic antibiotic 89-07 was obtained. The structures of the antibitoic and itssemisvnthetic inter mediate were elucidated by means of IR, UV, MS. 1H-NMR, 13C-NMR, DEPT,1H-1H-Cosy, 13C-1H-COSY and were identical with that of 1-N-ethyl-GMC1a and3,2' ,6'-tri-N- acetyl-GMC1a (P1),3,2' ,6'-tri-1- N- ethy- GMC1a (P2) respectively. |
| Keywords: | Antibiotic 89-07 Synthesis Structure determination |
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