乳腺癌新辅助内分泌治疗对ER、PR、C—erbB-2表达的影响 |
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引用本文: | 管小青,吴骥,顾书成,陈焰,吴建强,吴际生,江小玲,侍孝红.乳腺癌新辅助内分泌治疗对ER、PR、C—erbB-2表达的影响[J].内分泌外科杂志,2009,3(3):158-160. |
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作者姓名: | 管小青 吴骥 顾书成 陈焰 吴建强 吴际生 江小玲 侍孝红 |
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作者单位: | 1. 南京鼓楼医院集团宿迁市人民医院乳腺外科, 宿迁,223800 2. 南京鼓楼医院集团宿迁市人民医院病理科, 宿迁,223800 |
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基金项目: | 江苏省科技厅社会发展摹金资助课题 |
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摘 要: | 目的探讨60岁以上绝经后期乳腺癌患者术前行内分泌治疗对ER、PR、C—erbB-2表达的影响及其意义。方法本组36例每日口服三苯氧胺两次,一次10mg,疗程60~90d。在新辅助内分泌治疗前、后均行ER、PR、C—erbB-2测定。结果36例ER、PR阴性表达率在新辅助内分泌治疗前分别为16.78%、11.11%;治疗后分别为50%、33.33%差异有统计学意义(P〈0.05)。C—erbB-2在新辅助内分泌治疗前后表达率分别为13.89%、16.67%,差异无统计学意义(P〉0.05)。结论单用三苯氧胺可下调ER、PR的表达,抑制肿瘤生长,使部分病例获得缓解。
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关 键 词: | 新辅助内分泌治疗 乳腺癌 ER PR C—erbB-2 |
The effects of neoadjuvant endocrine therapy on expressions of ER, PR and C-erbB-2 in breast cancer patients |
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Authors: | GUAN Xiao-qing WU Ji GU Shu-cheng CHEN Yan WU Jian-qiang WU Ji-sheng JIANG Xiao-ling SHI Xiao-hong |
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Institution: | GUAN Xiao-qing , WU Ji , GU Shu-cheng , CHEN Yan , WU Jian-qiang , WU Ji-sheng , JIANG Xiao-ling , SHI Xiao-hong. (Department of Breast Surgery,Suqian People's Hospital, Nanjing Drum-Towl Hospital Group, Suqian 223800, China) |
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Abstract: | Objective To explore the effects of preoperative neoadjuvant endocrine therapy on expression and significance of ER, PR, C-erbB-2 in pestmenopause breast cancer patients over 60 years old. Methods 36 patients were treated with endrocrine therapy by oral tamoxifen for 60 ~ 90 days, and the expression of ER, PR and C-erbB-2 was examined before and after the endrocrine therapy. Results In 36 patients the negative expres-sion rate of ER, PR was 16.78% and 11.11% respectively before the endrocrine therapy, compared to 50% and 33.33% after the endrocrine therapy. There was significant difference(P<0.05). The expression of C-erbB-2 was 13.8% and 16.67% before and after the endrocrine therapy, and there was no significant difference between the two figures. Conclusions The neoadjuvant endocrine therapy by tamoxifen alone can down-regulate the ex-pression of ER, PR, and can inhibit tumor growth. Some patients may get partially relieved. |
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Keywords: | ER PR C-erbB-2 Neoadjuvant endocrine therapy Breast cancer ER PR C-erbB-2 |
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