东莞地区6 178名妇女人乳头瘤病毒感染率及型别分布情况

目的 探讨东莞地区各年龄段妇女人乳头瘤病毒的感染率以及型别的分布情况,为临床防治措施的制定提供参考依据。 方法 选取2012年1月-2015年10月期间在广东省东莞市计划生育服务中心妇科门诊就诊,接受人乳头瘤病毒检测的患者6 178例为研究对象。将1 232例30岁以下的患者为A组,1 244例31~40岁的患者为B组,1 238例41~50岁的患者为C组,1 235例51~60岁的患者为D组,1 229例61~70岁的患者为E组。统计人乳头瘤病毒的感染率以及不同型别人乳头瘤病毒的分布情况,同时对比5组患者人乳头瘤病毒的感染率以及不同型别的分布情况。 结果 本研究检出1 069例人乳头瘤病毒阳性,阳性率为17.30%,其中HR-HPV检出771例(占72.12%),LR-HPV检出142例(占13.28%),不确定型检出156例(占14.59%)。HR-HPV以HPV-16、HPV-52、HPV-58、HPV-18和HPV-51较为常见,分别占阳性样本的18.80%、14.03%、9.54%、7.76%和6.27%。各组患者人乳头瘤病毒检出率以及HR-HPV检出率的对比,差异有统计学意义(均P＜0.05)。A组患者人乳头瘤病毒的检出率最高,为31.25%,HR-HPV的检出率也最高,为22.24%,而E组患者人乳头瘤病毒的检出率最低,为5.70%,HR-HPV的检出率也最低,为3.66%。各组患者LR-HPV、不确定型以及混合感染的检出率对比,差异均无统计学意义(均P＞0.05)。 结论 东莞地区妇女人乳头瘤病毒感染率居中,以HR-HPV为主,且30岁以内有性生活妇女的感染率较高。

Infection rate and distribution of HPV in 6,178 women in Dongguan area

Objective To investigate the infection rate and distribution of human papilloma virus (HPV) in women in Dongguan area, and to provide reference for clinical prevention and control measures. Methods Totally, 6,178 patients with HPV detection in gynecology clinic of Family Planning Service Center of Dongguan in Guangdong Province were selected as research objects. 1,232 patients under 30 years old were recruited into group A, 1,244 cases of 31-40 years old into group B, 1,238 cases of 41-50 years old into group C, 1,235 cases of 51-60 years old into group D and 1,229 cases of 61-70 years old into group E. The infection rate of HPV and the distribution of different virus types of HPV were statistically analyzed and compared among different groups. Results HPV was detected in 1,069 cases, with a positive rate of 17.30%. Among them, 771 cases (72.12%) were detected to have high risk HPV (HR-HPV), 142 cases (13.28%) to have low risk HPV (LR-HPV), and 156 cases to have uncertain type(14.59%). As for HR-HPV, HPV-16, HPV-52, HPV-58, HPV-18 and HPV-51 were common, accounting for 18.80%, 14.03%, 9.54%, 7.76% and 6.27% respectively in the positive samples. The detection rates of HPV and HR-HPV differed significantly among various groups(P＜0.05), with the highest rates in group A (31.25% and 22.24%), and the lowest in group E (5.70% and 3.66%). The detection rates of LR-HPV, uncertain type and mixed infection were not statistically different among various groups(P>0.05). Conclusions The infection rate of HPV in women in Dongguan area is median, and HR-HPV is predominant. The women younger than 30 years with active sexual life have higher infection rate.