固本止咳膏的药效研究

目的 :观察固本止咳膏镇咳、祛痰、平喘、抗炎的药理作用。方法 :用SO2 与氨水 (NH4 OH)引咳小鼠法观察固本止咳膏的镇咳作用 ;用酚红与毛细管排痰法观察固本止咳膏的祛痰作用 ;用喷雾致喘法观察固本止咳膏的平喘作用 ;用角叉菜胶与棉球植入法观察固本止咳膏的抗炎作用。结果 :固本止咳膏对SO2 、氨水引咳的小鼠可明显延长引咳潜伏期 ,减少咳嗽次数 ;显著增加小鼠呼吸道粘膜酚红的排出量 ,增加大鼠呼吸道内痰液的分泌量 ;可延长乙酰胆碱和组织胺混合液所致豚鼠哮喘的潜伏期 ;对大鼠急、慢性炎症模型均呈现抗炎作用。结论 :固本止咳膏具有镇咳、祛痰、平喘和抗炎作用

Pharmacodynamic Study on Guben Zhike Gao

Objective:observe the effect of Guben Zhike Gao on expelling phlegm,relieving coungh and asthma and resisting inflammation.Methods:The coungh relieving effect of Guben Zhike Gao was observed by mouse cough model induced by SO 2 and NH 4OH with Capillary method. Observation on the phlegmexpelling effect was completed by using phenol red. Observation on the asthma relieving effect was completed by inducing asthma with Ach histamine method in quinea pig. The anti inflammation effect of Guben Zhike Gao was investigated by implantation of carrageenin and cotton ball in rat. Results:The Guben Zhike Gao can prolong apparently the coughing incubation period and reduce coughing frequency;increase excretion of phenol red and phlegm from the respiratory tract; prolong the incubation period of asthma due to Ach histamine solution and resist inflammation on acute and chronic inflammator models. Conclutions:The Guben Zhike Gao has the functions of expelling phlegm,relieving cough and asthma,resisting inflammation.