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| TrkB/BDNF在非小细胞肺癌组织中的表达及临床意义 | |
| 引用本文： | 金常娥,邱晨,傅应云,吴迪,张向霞,狄红红. TrkB/BDNF在非小细胞肺癌组织中的表达及临床意义[J]. 微循环学杂志, 2011, 21(4): 23-25,7,11 |
| 作者姓名： | 金常娥 邱晨 傅应云 吴迪 张向霞 狄红红 |
| 作者单位： | 1. 暨南大学第二临床医学院,广东省深圳市人民医院呼吸内科,深圳518020 2. 华中科技大学附属同济医院呼吸内科 |
| 摘 要： | 目的:探讨肿瘤标记物TrkB/BDNF在非小细胞肺癌癌组织中的表达及其临床意义。方法:采用免疫组化(SP法)和Realtime-PCR方法检测非小细胞肺癌组织和癌旁组织中TrkB/BDNF的mRNA表达水平,并分析其在相关临床因素间的差异。结果:非小细胞肺癌癌组织TrkB/BDNF表达阳性,且明显高于癌旁组织。TrkB/BDNFmRNA水平在有否脑转移和不同TNM分期之间存在明显差异(P<0.05);而在性别、年龄、吸烟、肿瘤大小、分化程度、病理组织学类型间无显著差异(P>0.05)。结论:TrkB/BDNF在非小细胞肺癌癌组织中高表达,并与其脑转移、TNM分期有关,两者可能在非小细胞肺癌的侵袭及转移(尤其脑转移)中发挥重要作用。 |
| 关 键 词： | 非小细胞肺癌 TrkB/BDNF 转移 |
Expression and Clinical Significance of TrkB/BDNF in Non-Small Cell Lung Cancer |
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| Jin Chang'e,Qiu Chen,Fu Yingyun,et al. Expression and Clinical Significance of TrkB/BDNF in Non-Small Cell Lung Cancer[J]. Chinese Journal of Microcirculation, 2011, 21(4): 23-25,7,11 | |
| Authors: | Jin Chang'e Qiu Chen Fu Yingyun et al |
| Affiliation: | Jin Chang'e,Qiu Chen,Fu Yingyun,et al Department of Respiratory Medicine,the Second Chinical Medical College of Jinan University,People's Hospital of Shenzhen,Shenzhen 518020 |
| Abstract: | Objective:To investigate the expression of TrkB/BDNF in non-small cell lung cancer(NSCLC) and to explore their clinical significance.Method:TrkB and BDNF expression were examined in NSCLC and tumor-adjacent tissues by immunohistochemistry,RT-PCR,also their relation with clinical features were analyzed.Results:The positive rate of TrkB/BDNF protein were significantly higher in NSCLC than that of tissues adjacent to carcinamo tissues.The mRNA expression of TrkB/BDNF were significantly higher in NSCLC tissues.... |
| Keywords: | Non-small cell lung cancer TrkB/BDNF Metastasis |
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