急性心肌梗塞患者脂质过氧化物及相关酶的测定与分析

测定了92例急性心肌梗塞患者血超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GSH－PX），丙二醛（MDA），发现AMI患者SOD，GSH－PX明显低于正常人，MDA明显高于正常人。这种变化的幅度因AMI的临床表现不同而异，AMI合并心衰，室速者MDA升高，SOD，GSH－PX降低最显著．提示上述指标与心肌缺血的严重程度有关．AMI患者脂质过氧化物及相关酶的测定对判断其预后有一定指导意义。

The Study of Free Radical Injury in Patients with Acute Myocardial Infarction

In order to clarify the correlation between free radicals(FR) and ventricular tachycardia (VT) orheart failure (HF) in acute myocardial infartion (AMI), patients the superoxide dismutase (SOD), gluthathioneperoxidase (GSH-PX) activity and malondialdehyde (MDA) conent in blood of 92 patients were determined. Anincrease in MDA content and a decrease in an and GSH - PX activity were observed in 10 patients with complcated VT and 18 patients with HF, comparing with 47 noncomplicated AMI patients. It was suggested that FR playsan important role in the development of VT and HF in AMI patients.