| 羧烷基化合成萘普生工艺改进 |
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| 引用本文： | 郭峰,黄光斗,赵枢密,雷晓东. 羧烷基化合成萘普生工艺改进[J]. 中国现代应用药学, 1998, 15(2): 32-33 |
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| 作者姓名： | 郭峰 黄光斗 赵枢密 雷晓东 |
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| 作者单位： | 1. 湖北工学院化工系，武汉 430068
2. 本院九六届毕业生现在襄樊化工厂 |
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| 基金项目： | 湖北工学院青年基金项目 |
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| 摘 要： | １－溴－２－甲氧基萘与０－对在苯磺酰乳酸乙酯（１）在无水氯化铝催化下化Ｆｒｉｅｄｅｌ－Ｃｒａｆｔｓ反应，还原脱溴直接合成ｄｌ－１ａ萘普生（３），以上反应均在“一锅”内完成，收率达９５。
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| 关 键 词： | 萘普生 还原脱溴 工艺 羧烷基化 |
Improved synthesis of dl-naproxen by carboxylation-alkylation |
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| Guo Feng ( Guo F ,Huang Guangdou ( Huang GD ,Lei Xiaodong ( Lei XD ,et al. Improved synthesis of dl-naproxen by carboxylation-alkylation[J]. The Chinese Journal of Modern Applied Pharmacy, 1998, 15(2): 32-33 |
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| Authors: | Guo Feng ( Guo F Huang Guangdou ( Huang GD Lei Xiaodong ( Lei XD et al |
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| Abstract: | dl-Naproxen was directly synthesized via reduction and hydrolysis of ethyl (5-bromo-6-methoxy-2-naphthyl )-a -methyl acetate (2), which was prepared by Friedel-Crafts reaction with 1-bromo-2methoxynaphthalene and ethyl 0-(p-methyl benzene sulfonyl) lactate under the catalysis of anhydrous AlCl3, all reactions were carried out in one-pot to afford dl-naproxen in about 95% yield from 1-bromo-2-metboxynaphthalene. |
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| Keywords: | dl-naproxen friedel-crafts reaction reduction-debromination |
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