| 紫外分光光度法测定复方酮康唑软膏中酮康唑和氧氟沙星的含量 |
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| 引用本文： | 张守尧,沈霞,王桂芳,邓葛峰. 紫外分光光度法测定复方酮康唑软膏中酮康唑和氧氟沙星的含量[J]. 中国现代应用药学, 1998, 18(4): 43-44 |
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| 作者姓名： | 张守尧 沈霞 王桂芳 邓葛峰 |
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| 作者单位： | 1. 广州,510282,第一军医大学珠江医院
2. 黄山,解放军532医院 |
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| 摘 要： | 目的：建立复方酮康唑软膏的含量测定方法。方法：用双波长分光光度法测定酮康唑的含量，用单波长法测定氧氟沙星的含量。结果：两被测组分的平均回收率和相对标准偏差分别为酮康唑１００．３３％和０．３２％；氧氟沙星１００．８５％和０．２７％。结论：方法简便、准确，可用于复方酮康唑软膏的质量控制。
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| 关 键 词： | 分光光度法 复方酮康唑软膏 酮康唑 氧氟沙星 |
Determination of ketoconazole and ofloxacin in compound ketoconazole ointment by ultroviolet spectrophotometry |
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| Zhang Shouyao(Zhang SY,Shen Xia(Shen X,Wang Guifang(Wang GF,et al. Determination of ketoconazole and ofloxacin in compound ketoconazole ointment by ultroviolet spectrophotometry[J]. The Chinese Journal of Modern Applied Pharmacy, 1998, 18(4): 43-44 |
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| Authors: | Zhang Shouyao(Zhang SY Shen Xia(Shen X Wang Guifang(Wang GF et al |
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| Abstract: | OBJECTIVE: To establish a accurate method for the determination of ketoconazole and ofloxacin in compound ketoconazole ointment. METHODS: A dual - wavelength spectrophotometry method was used for the determination of ketoconazole and ultroviolet spectrophotometry method for ofloxacin. RESULTS: The average recoveries and relative standard deviations were 100. 33%, 0. 32% for ketoconazole and 100. 85%, 0. 27% for ofloxacin. CONCLUSION:The method was simple and accurate and can be used for the quality control of compound ketoconazole ointment. |
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| Keywords: | dual - wavelength spectrophotometry ketoconazole ofloxacin compound ketoconazole ointment |
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