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| Studies on the Expression of MMP-9 and Significance ofa Macrophage Assay in Oral Squamous Cell Carcinoma | |
| 引用本文： | Taiming Dai Yufeng Song Hong Ma Hongchao Feng. Studies on the Expression of MMP-9 and Significance ofa Macrophage Assay in Oral Squamous Cell Carcinoma[J]. 中国肿瘤临床(英文版), 2007, 4(5): 333-337. DOI: 10.1007/s11805-007-0333-z |
| 作者姓名： | Taiming Dai Yufeng Song Hong Ma Hongchao Feng |
| 作者单位： | Taiming Dai Yufeng Song Hong Ma Hongchao Feng Department of Oral and Maxil ofacial Surgery，the Affiliated Hospital of Guiyang Medical University，Guiyang 550004，China. |
| 摘 要： | OBJECTIVE To investigate the significance and relationship between matrix metaloproteinase 9(MMP-9)and infiltration of macrophages in the process of invasion and metastasis in oral squamous cel carcinoma(OSCC). METHODS The immunohistochemical SABC method was used to detect the expression of MMP-9 and CD68(for labeling macrophages)in 42 cases of OSCC and in 10 normal tissues. RESULTS The expression of MMP-9 and macrophage counts in the OSCC cases were significantly higher compared to normal tissues(P<0.05). The expression of MMP-9 and macrophage counts were related to lymphnode metastasis and the TNM stage(P<0.05),showing that there was a positive correlation among these parameters(γ=0.443,P<0.01). CONCLUSION Both MMP-9 and macrophages may play an important role in the process of invasion and metastasis in OSCC,and this cel ular activity may relate to the macrophages which affect the tumor cells and upregulate the expression of MMP-9. |
| 关 键 词： | 上皮细胞 矩阵 巨噬细胞 癌症 |
| 收稿时间： | 2007-07-28 |
| 修稿时间： | 2007-07-28 |
Studies on the expression of MMP-9 and significance of a macrophage assay in oral squamous cell carcinoma |
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| Taiming Dai,Yufeng Song,Hong Ma,Hongchao Feng. Studies on the expression of MMP-9 and significance of a macrophage assay in oral squamous cell carcinoma[J]. Chinese Journal of Clinical Oncology, 2007, 4(5): 333-337. DOI: 10.1007/s11805-007-0333-z | |
| Authors: | Taiming Dai Yufeng Song Hong Ma Hongchao Feng |
| Affiliation: | Department of Oral and Maxillofacial Surgery,the Affiliated Hospital of Guiyang Medical University,Guiyang 550004,China |
| Abstract: | Objective To investigate the significance and relationship between matrix metalloproteinase 9 (MMP-9) and infiltration of macrophages in the process of invasion and metastasis in oral squamous cell carcinoma (OSCC). Methods The immunohistochemical SABC method was used to detect the expression of MMP-9 and CD68 (for labeling macrophages) in 42 cases of OSCC and in 10 normal tissues. Results The expression of MMP-9 and macrophage counts in the OSCC cases were significantly higher compared to normal tissues (P<0.05). The expression of MMP-9 and macrophage counts were related to lymphnode metastasis and the TNM stage (P<0.05), showing that there was a positive correlation among these parameters (γ = 0.443, P<0.01). Conclusion Both MMP-9 and macrophages may play an important role in the process of invasion and metastasis in OSCC, and this cellular activity may relate to the macrophages which affect the tumor cells and up-regulate the expression of MMP-9. This work was supported by the National Natural Science Foundation of China (No. 30660200), and the Provincial Governor’s Special Fund of Guizhou Province, China (No. 005-160). |
| Keywords: | oral squamous cell carcinoma matrix metalloproteinase-9 macrophage immunohistochemistry |
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