| 新疆子宫颈癌的端粒酶活性研究 |
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| 引用本文： | 孙力 周祖钊 等. 新疆子宫颈癌的端粒酶活性研究[J]. 肿瘤研究与临床, 2000, 12(6): 386-388 |
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| 作者姓名： | 孙力 周祖钊 等 |
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| 作者单位： | [1]新疆医科大学附属肿瘤，新疆乌鲁木齐830011 [2]新疆石河子大学医学院，新疆石河子832000 |
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| 基金项目： | 新疆维吾尔自治区教委科研基金资助项目 |
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| 摘 要： | 目的：探讨端粒酶活性与宫颈癌发生发展的关系及其在宫颈癌中的临床诊断价值。方法：用TRAP－ELISA法检测34例宫颈癌和21例正常宫颈的新鲜组织及脱落细胞标本的端粒酶活性，并进行比较。结果：宫颈癌细胞中端粒酶阳性检出率为88．2％，显著高于正常宫颈细胞的阳性检出率（9．5％），端粒酶活性水平与宫颈癌临床分期，组织学分化无关。脱落细胞检测宫颈细胞的端粒酶活性与新鲜组织检测的结果一致。结论：端粒酶活性可作为宫颈癌的肿瘤标记物。用TRAP－ELISA法对宫颈脱落细胞行端粒酶检测有助于宫颈癌的筛查。
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| 关 键 词： | 子宫颈肿瘤 端粒酶活性 肿瘤标记物 |
TELOMERASE ACTIVITY OF CERVICAL CANCER IN XINJIANG |
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| SUN Li,LI Ting fang,ZHOU Zu zhao,et al Affiliated Tumor Hospital,Xinjiang Medical University. TELOMERASE ACTIVITY OF CERVICAL CANCER IN XINJIANG[J]. Cancer Research and Clinic, 2000, 12(6): 386-388 |
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| Authors: | SUN Li LI Ting fang ZHOU Zu zhao et al Affiliated Tumor Hospital Xinjiang Medical University |
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| Abstract: | Objective:To investigate the diagnostic significance of detection of telomerase activity in cells from cervical cancer,and to investigate the relationship between telomerase expression and progression of cervical carcinoma.Methods:A total of 55 biopys samples and cervical scraping samples obtained from 34 cases of cervical cancer and 21 cases of normal cervix were examined for telomerase activity by TRAP-ELISA.Results:Thirty of 34(88.2%) cervical cancer specimens form normal cervices showed telomerase.Telomerase activity was not correlated with clinical stage and grade.Cervical exfoliated cell can be used for telomerase assay.Conclusion:Telomerase expression could be used asa tumor marker and detector of telomerase activity in the exfoliated cells obtained form cervical scrapings,and may be useful in screening cervical cancer. |
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| Keywords: | Cervix neoplasms Telomerase activity Tumor marker |
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