基于fMRI技术观察中西医结合治疗对急性缺血性脑卒中默认网络的影响

目的 采用静息态功能磁共振成像(fMRI)技术,观察疏血通注射液联合常规治疗(中西医结合治疗)对急性缺血性脑卒中患者的临床疗效,并探讨默认网络(DMN)内功能连接的改变,揭示潜在的疗效机制.方法 纳入20例急性缺血性脑卒中患者在中西医结合治疗前后行fMRI,同时选取20例健康受试者作对照,比较患者和健康受试DMN内功能...

Effect of the Integrated Chinese and Western Medicine on the Default Mode Network in the Acute Ischemic Stroke Based on fMRI

OBJECTIVE  To observe the clinical efficacy of Shuxuetong injection combined with conventional treatment on acute ischemic stroke using resting-state functional magnetic resonance imaging (fMRI), and to investigate the changes of functional connectivity within the default mode network (DMN) to reveal the potential mechanism of efficacy.METHODS  A total of 20 patients with acute ischemic stroke were included to undergo fMRI before and after the integrated Chinese and Western medicine treatment, while 20 healthy subjects were selected as controls to compare the differences within the DMN between patients and healthy subjects. In addition, the differences in clinical scale scores and functional connectivity within the DMN between patients before and after treatment were also compared to further analyze the correlation between the differential encephalic region and clinical scale scores.RESULTS  ① After treatment, patients' NIHSS and mRS scores reduced significantly, BI scores increased significantly (P < 0.01), and diagnosis scores of Chinese medicine disease category improved significantly (P < 0.01). ②Compared with healthy subjects, the functional connectivity of the right superior temporal gyrus and right precuneus in DMN of patients before treatment reduced significantly (P < 0.05), and there was no significant difference in DMN of patients after treatment (P>0.05). The functional connectivity of the right posterior cingulate gyrus and the right precuneus in the DMN enhanced significantly after treatment compared with that before treatment (P < 0.05). ③The change in the functional connectivity of the right precuneus was significantly correlated with the NIHSS and BI scores (P < 0.01).CONCLUSION  Integrated treatment of ischemic stroke with Chinese and Western medicine may reduce neurologic impairment and improve the living quality by modulating the functional connectivity of the right precuneus in the DMN.