加味三黄石膏汤治疗痰热壅肺型支气管扩张急性发作期临床研究

目的:观察加味三黄石膏汤治疗痰热壅肺型支气管扩张急性发作期的临床疗效。方法:将50例痰热壅肺型支气管扩张急性发作期患者按照随机数字表法分为治疗组和对照组各25例。对照组予西药治疗,治疗组予加味三黄石膏汤治疗,2组均治疗2周。观察治疗前后中医证候积分、Karnofsky评分、血常规及肺功能等相关指标的变化,治疗后评价临床疗效。结果:治疗组总有效率96.0%,高于对照组的64.0%,差异有统计学意义(P<0.05)。治疗组生活质量提高率80.0%,高于对照组的24.0%,差异有统计学意义(P<0.05)。治疗组治疗后第1秒用力呼气量(FEV1)较治疗前增加,差异有统计学意义(P<0.05);组间比较,差异无统计学意义(P>0.05)。2组FEV1/用力肺活量(FVC)比值同组治疗前后和治疗后组间比较,差异均无统计学意义(P>0.05)。治疗后,2组白细胞计数(WBC)、超敏C-反应蛋白(hs-CRP)水平及治疗组中性粒细胞百分比(NE)水平均较治疗前降低,差异均有统计学意义(P<0.05);以上3项指标治疗后组间比较,差异均无统计学意义(P>0.05)。结论:加味三黄石膏汤治疗痰热壅肺型支气管扩张急性发作期疗效满意,能在抗感染的同时,改善患者的肺功能,提高其生活质量。

Clinical Study on Modified Sanhuang Shigao Tang for Bronchiectasis of Phlegm-heat Obstructing Lung Type in Acute Exacerbation

Objective:To observe the clinical effect of modified Sanhuang Shigao tang for bronchiectasis of phlegm-heat obstructing lung type in acute exacerbation.Methods:Divided 50 cases of patients with bronchiectasis of phlegm-heat obstructing lung type in acute exacerbation into the treatment group and the control group,25 cases in each group.The control group was given western medicine,while the treatment was given modified Sanhuang Shigao tang.Both groups received treatment for two weeks.Observed changes of Chinese medicine syndrome scores,Karnofsky scores,such relevant indexes as blood routine and lung function before and after treatment,and evaluated the clinical effect after treatment.Results:The total effective rate was 96.0%in the treatment group,being higher than 64.0%in the control group,difference being significant(P<0.05).The increasing rate of life quality was 80.0%in the treatment group,being higher than 24.0%in the control group,difference being significant(P<0.05).After treatment,forced expiratory volume in the first second(FEV1)in the treatment group was increased when compared with that before treatment,difference being significant(P<0.05);there was no significant difference being found in the comparison in-between the two groups(P>0.05).After treatment,comparing the ratios of FEV1 to forced vital capacity(FVC)in-between and within the two groups,there were no significant difference being found(P>0.05).After treatment,the levels of white blood cell count(WBC)and highsensitivity C-reactive protein(hs-CRP)and the percentage of neutrophil(NE)in both groups were lower than those before treatment,differences being significant(P<0.05);there were no significant differences being found when compared each index above in both groups.Conclusion:The therapy of modified Sanhuang Shigao tang has satisfying curative effect in treating bronchiectasis of phlegm-heat obstructing lung type in acute exacerbation.It can function as anti-infection,improve pulmonary ventilation function and the qualify of life.