幽门螺杆菌感染与慢性胃炎红细胞免疫功能变化的关系

目的 :探讨幽门螺杆菌感染与慢性胃炎患者红细胞免疫功能的影响。方法 :采用红细胞C3b受体花环 (RBC -C3bRR)试验、免疫复合物花环 (RBC -ICR)试验、免疫粘附促进因子 (RFER)　百分率及抑制因子 (RFIR)百分率试验 ,检测 3 15例慢性胃炎患者与 3 0例健康体检者红细胞免疫功能情况。结果 :慢性胃炎组RBC -C3bRR、RFER明显低于对照组 (P <0 0 1,P <0 0 5 ) ,RBC -ICR、RFIR高于对照组 ((P <0 0 5 ,P <0 0 1) ;Hp阳性组RBC -C3bRR明显低于Hp阴性组 (P <0 0 5 ) ,RBC -ECR明显高于HP阴性组 (P <0 0 5 ) ,RFER、RFIF两组间比较未见显著差异 ;对 186例Hp阳性根除治疗前、后红细胞免疫功能对比发现治疗后RBC -ICR明显低于根除前 ,其余指标无显著改变。结论 :Hp的感染可能导致宿主红细胞免疫功能紊乱 ,其感染可能是慢性胃炎患者红细胞免疫功能下降的主要原因。

The relationship between the infection of Helicobacter pylori and the changes of immunologic function of red blood cells in patients with chronic gastritis

Objective To investigate the changes of immunologic function of red blood cells(RBC)in patients with chronic gastritis infected by helicobacter pylori(HP).Methods The immunologic function of RBC in 315 cases of chronic gastritis was dynamically detected with yeast rosette method before and after treatment.Results The results showed that RBC-C 36 receptor rostte(RBC-C 36RR)rate and RBC immune adherence enhance factor(RFER) rates were lower(P<0.01, P<0.05)and RBC immune complex rosette (RBC-ICR)rate and RBC immune adherence inhibitor factor(RFIR)were higher( P<0.05,P<0.01)in patients with chronic gastritis than those in control group.RBC-C 36RR was obviously lower and PBC-ICR was obviously higher in patients with chronic gastritis infected by HP than those with no HP(P<0.05,P<0.05).There was no great difference in RFER and RFIF between these two groups.RBC-ICR was significantly lower after treatment in 186 patients infected by HP and needing eradication.Conclusions HP infection could reduce immunologic function of RBC in patients with chronic gastritis.