| PTEN,CyclinD1在皮肤鳞状细胞癌中的表达和意义 |
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| 引用本文： | 李灵,杨红,李科,董丹丹. PTEN,CyclinD1在皮肤鳞状细胞癌中的表达和意义[J]. 四川医学, 2011, 32(1): 16-18 |
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| 作者姓名： | 李灵 杨红 李科 董丹丹 |
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| 作者单位： | 四川省人民医院皮肤性病研究所,病理科,四川,成都,610072 |
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| 摘 要： | 目的观察PTEN,CyclinD1在皮肤鳞状细胞癌组织中的表达,探讨PTEN,CyclinD1在皮肤鳞状细胞癌发生发展中的作用。方法用免疫组织化学技术检测25例皮肤鳞癌石蜡包埋组织和10例正常皮肤组织的PTEN、Cy-clinD1表达。结果 CyclinD1在皮肤鳞癌组织中表达高于皮肤正常对照组,两者差异有统计学意义（P〈0.01）;PTEN在皮肤鳞癌组织中表达低于皮肤正常对照组,但两者差异无统计学意义（P〉0.05）;PTEN、CyclinD1在皮肤鳞癌中表达呈正相关性（r=0.782,P〈0.01）。结论 CyclinD1在皮肤鳞状细胞癌组织中阳性表达上调,PTEN在皮肤鳞状细胞癌组织中阳性表达异常,PTEN,CyclinD1在皮肤鳞癌中表达呈正相关。
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| 关 键 词： | CyclinD1 PTEN 皮肤鳞状细胞癌 |
The expression and significances of PTEN, CyclinD1 in cutaneous squamous carcinoma |
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| Affiliation: | LI Ling,YANG Hong,LI Ke,et al.The People′s Hospital of Sichuan,Chengdu,Sichuan 610072,China |
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| Abstract: | Objective To observe the expression of CyclinD1,PTEN in cutaneous squamous carcinoma and to study the relationship with the genesis and development of cutaneous squamous cell carcinoma.Methods A totle of 25 specimens of cutaneous squamous carcinoma were evaluated by inmmunohistochmeical technique with monoclonal antibody for the expression of CyclinD1,PTEN.Results The positive expression rate of CyclinD1,in cutaneous squamous cell carcinoma was significantly higher compared to normal skin(P<0.01).The positi... |
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| Keywords: | CyclinD1 PTEN cutaneous squamous cell carcinoma |
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