苦参碱制剂的临床应用研究进展

目的:总结苦参碱制剂近年来的研究开发和临床应用研究进展.方法:查阅近10余年国内外相关文献及研究资料,并对其分析,归纳和总结.结果:目前临床应用的苦参碱剂型主要为注射剂、胶囊剂、片剂和栓剂,而正在研制中的剂型有缓控释制剂、透皮吸收制荆和靶向制剂等,由于苦参碱具有广泛的药理作用,近年来在治疗慢性肝炎和肝纤维化等方面得到了广泛的应用.结论:对苦参碱的现有制剂进行现代化的改良,或研究开发新型制剂,将有助于提高其疗效,对于全面开发利用苦参碱有深远的意义.

Progress on Clinical Application of Matrine Preparation

Objective： To summarize the progress of clinical application and development of research on matrine preparation in recent years.Method： Associated literature and data at home and abroad in more than ten years were retrieved,analyzed,concluded and summed up.Result： Main preparations of matrine included injection,capsule,tablets and suppository in clinical application nowadays,while preparations under developing were sustained-release preparations,transdermal drug delivery preparations and targeting preparations.Matrine was widely used in treating chronic hepatitis and hepatic fibrosis in recent years with extensive pharmacological action.Conclusion： Modern reform on present preparations of matrine or development on new preparations would be helpful to raise the effects and meaningful to full development and application of matrine.