| 五加皮遗传毒性实验研究 |
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| 引用本文： | 刘冰,庞慧民,陆培信.五加皮遗传毒性实验研究[J].吉林大学学报(医学版),1999,25(4):346-348. |
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| 作者姓名： | 刘冰 庞慧民 陆培信 |
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| 作者单位： | 基础医学院医学遗传学教研室，长春 130021 |
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| 基金项目： | 国家自然科学基金;39170942; |
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| 摘 要： | 目的：探讨五加皮对小鼠体细胞和生殖细胞的遗传毒性。方法：采用小鼠骨髓细胞微核试验（ Ｍ Ｎ Ｔ）、骨髓和睾丸染色体畸变（ Ｃ Ａ）试验以及精子畸形试验。结果：五加皮诱发的微核、染色体畸变和精子畸形均低于正常对照，特别是精子畸形率明显低于正常对照（ Ｐ＜ ００１）。结论：五加皮对小鼠体细胞和生殖细胞均无诱变损伤作用。
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| 关 键 词： | 五加皮 微核 染色体畸变 精子畸形 |
| 修稿时间： | 1998年10月16日 |
Experimental study on genetic toxicity of cortex acanthopanasia radicis |
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| Liu Bing,Pang Huimin,Lu Peixin.Experimental study on genetic toxicity of cortex acanthopanasia radicis[J].Journal of Jilin University: Med Ed,1999,25(4):346-348. |
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| Authors: | Liu Bing Pang Huimin Lu Peixin |
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| Institution: | Department of Medical Genetics |
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| Abstract: | Objective:To study the genetic toxicity of cortex acanthopanasia radicis (CAR) on somatic cells and germ cells.Methods:The test of micronucleus (MN) and chromosome aberration (CA) of mouse bone marrow cells,the chromosome aberration of spermatogonia and sperm aberration were used.Kunming mice were randomly divided into five groups:normal saline control group (NS),MMC control group (MMC 1.0 mg/kg),CAR mutate group (CAR 1,2,4 g/kg.Results:The rates of MN in mouse bone marrow and chromosome aberration of somatic cell and germ cell induced by CAR were lower than those of NS group ( P >0 05).The rate of abnormal sperm induced by CAR was significantly lower,compared with NS group;the difference was significant ( P <0 01).Conclusion: CAR did not bring about any genetic damage on somatic cells and germ cells. |
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| Keywords: | cortex acanthopanasia radicis (CAR) micronucleus (MN) chromosome aberration (CA) sperm aberration |
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