微流控技术在纳米药物载体制备中的应用

微流控技术是一种在微纳米尺度空间中对流体进行精确控制和操纵的科学技术,具有将生物、化学等实验室的基本功能包括样品制备、反应、分离和检测等微缩到一个几平方厘米芯片上的能力,目前也成为纳米医药领域的研究热点之一。与传统制备纳米材料的方法相比较,微流控技术在纳米药物载体开发中具有许多优势,如能够精确控制结构、批次间重复性高、快速有效等。笔者将简要介绍微流控技术及其在聚合物纳米粒、脂质纳米粒和杂化纳米粒等纳米药物载体制备中的应用,同时也为今后研究者如何选择准确合理的微流控技术制备纳米药物载体提供思路与参考,并对其未来的发展和挑战进行展望。

Application of Microfluidic Technology for Preparation of Nanoparticle Drug Carriers

Microfluidic technology is a scientific technology that precisely controls and manipulates fluids in micro-nano-scale space,and has become one of the research hotspots in the field of nanomedicine.It has the ability to scale the basic functions of biological and chemical laboratories,including sample preparation,reaction,separation and detection,to a few square centimeters of chip.Compared with traditional approaches,microfluidic technology is equipped with many advantages in the development of nanomedicine carriers,such as controlling quality precisely,high reproducibility,fast and effective.Herein,this paper provides the brief introduction about the microfluidic technology and its application in the preparation of nanoparticulate drug carriers,which including polymer nanoparticles,lipid nanoparticles and hybrid nanoparticles.This review will provide ideas and references in utilization of microfluidic technology accurately and reasonably and also bring some prospects for its future development and challenges.