| 姜黄中3个新的没药烷型倍半萜类化合物 |
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| 引用本文： | 张莹莹,张萱,李文春,陈绍田,陈佳.姜黄中3个新的没药烷型倍半萜类化合物[J].中草药,2023,54(14):4420-4426. |
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| 作者姓名： | 张莹莹 张萱 李文春 陈绍田 陈佳 |
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| 作者单位： | 云南中医药大学云南省傣医药与彝医药重点实验室, 云南 昆明 650500;云南中医药大学中药学院, 云南 昆明 650500 |
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| 基金项目： | 国家自然科学基金委员会地区基金项目（82060785）；云南省科技厅基础研究计划中医联合项目面上项目（202001AZ070001-027）；云南省科技厅科技计划项目-基础研究专项（202301AT070257） |
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| 摘 要： | 目的 研究姜黄Curcuma longa根部的化学成分。方法 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱和HPLC等色谱技术进行分离纯化，通过理化性质与波谱数据分析鉴定结构。结果 从姜黄根部热水提取部位中分离得到10个化合物，分别鉴定为姜黄酮G（1）、姜黄酮H（2）、11-羟基-红没药-1,3(15),9-三烯（3）、香草醇（4）、甜没药姜黄醇（5）、甜没药姜黄醇B（6）、intermedin B（7）、longpene C（8）、3-(4-羟基-3-甲氧基苯基)丙烷-1,2-二醇（9）、(±)-松脂醇（10）。结论 化合物1～3为新化合物，其中化合物1和2互为差向异构体；化合物9、10为首次从姜黄中分离得到。
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| 关 键 词： | 姜黄 姜黄酮G 姜黄酮H 11-羟基-红没药-1 3(15) 9-三烯 (±)-松脂醇 |
| 收稿时间： | 2023/2/7 0:00:00 |
Three new bisabolene-type sesquiterpenoid from Curcuma longa |
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| ZHANG Ying-ying,ZHANG Xuan,LI Wen-chun,CHEN Shao-tian,CHEN Jia.Three new bisabolene-type sesquiterpenoid from Curcuma longa[J].Chinese Traditional and Herbal Drugs,2023,54(14):4420-4426. |
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| Authors: | ZHANG Ying-ying ZHANG Xuan LI Wen-chun CHEN Shao-tian CHEN Jia |
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| Institution: | Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming 650500, China;College of Traditional Chinese medicine, Yunnan University of Chinese Medicine, Kunming 650500, China |
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| Abstract: | Objective To study the chemical constituents of hot water extraction from the root of Curcuma longa. Methods The various chromatographic techniques, such as macro-porous resin, silica gel column chromatographic and semi-prep HPLC were used isolate and purify compounds from the hot water extraction of C. longa root. The structures of these compounds were identified by analysis of physicochemical property and spectroscopic data. Results Ten compounds were isolated and identified as turmerones G (1), turmerones H (2), 11-hydroxy-bisabola-1,3(15),9-triene (3), vanillyl alcohol (4), bisacurone (5), bisacurone B (6), intermedin B (7), longpene C (8), 3-(4-hydroxy-3-methoxyphenyl)propane-1,2-diol (9), (±)-pinoresinol (10). Conclusion Compounds 1-3 are new compounds, wherein compounds 1 and 2 are epimers; And compounds 9, 10 were isolated from C. longa root for the first time. |
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