维持性血液透析患者骨密度改变

为观察慢性肾衰维持性血透患者骨密度改变，要用ＤＥＸＡ方法测定１９５例维持性血透患者桡骨远端１／３点骨密度（ＢＭＤ），同时检测其血清中段甲状旁腺素（Ｍ－ＰＴＨ），碱性磷酸酶（ＡＬＰ）。结果显示血透患者骨密度低于相应年龄性别对照组，并随透析期间延长而更显突出。血透患者骨密度与ＰＴＨ，ＡＬＰ呈逆向改变关系。说明慢性肾衰血透患者存在骨量丢失，血透治疗似未能有效阻止其过程。骨密度测定对肾性骨病防治具有临床应

Changes of Bone Mineral Density in Hemodialysis Patients

To observe the changes and significance of bone mineral density (BMD) in hemodialysis(HD) patients with chronic renal failure (CRF),the BMD in distal 1/3 radius and phalanx were measured by dual energy x-ray absorptiometer (DEXA) in 195 patients with regular hemodialysis,serum PTH 44-68 (M-PTH),alkaline phosphatase (ALP) were determined simultaneously.The results showed that the BMD of HD patients were significantly lower than those of the sex-age matched group,and with prolongation of HD duration,the decrease became more obvious.There were negatively correlation among the BMD,PTH level and ALP activity in the HD patients.Therefore,the hemodialysis does not prevent the decrease of BMD in the HD patient with CRF,it suggests the measurement of BMD is a useful diagnostic method for renal osteodystrophy in HD patients with CFR.