脑血清颗粒对实验性家兔脑出血模型血液流变学指标的影响

目的通过测定血液流变学指标,探讨脑血清颗粒治疗家兔脑出血急性期的治疗作用机理。方法将造模成功的脑出血家兔随机分为清开灵组、脑血清颗粒剂组及生理盐水(NS)组,并分别于给药3d、7d后测血液流变学指标。结果给药3d后,大部分血液流变学指标(包括全血粘度、红细胞压积及全血还原粘度等)各组间差异均无显著性;给药7d后,NS组主要血液流变学指标都已降至正常值以下,而清开灵组及脑血清组对这种异常均有明显的改善作用。结论脑血清颗粒剂对兔脑出血的血液流变学指标有明显改善作用。

Study on Effect of Naoxueqing Granule on hemorheology Indices in Experimental Cerebral Hemorrhage Rabbits

Objective:To observe the effects of Naoxueqing Granules on the rabbit models of cerebral hemorrhage,by determining the hemorheology indices.Methods:The cerebral hemorrhage model rabbits were randomly divided into 4 groups:Qingkailing Injection treatment group;Naoxueqing Granule treatment group;model group and normal controlled group.After administration,the hemorhelology indices of each group were determined 3 or 7 days later.Results:3 days later, most of the hemorheology indices (including whole blood viscosity,HCT and whole reduced viscosity,etc)showed no difference among all of the groups. And 7 days later,the main indices of hemorheology decreased below the normal level.It was found both Qingkailing Injection and Naoxueqing Granule could significantly improve the abnormal hemorheology of rabbits with cerebral hemorrhage.Conclusion:Naoxueqing Granule can obviously improve the hemorheology of rabbits with cerebral hemorrhage.