Phenolic acid protects of renal damage induced by ochratoxin A in a 28-days-oral treatment in rats |
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| Affiliation: | 1. Facultad de QFB, Universidad Veracruzana, Xalapa, Ver., Mexico;2. Centro de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico;3. Doctorado en Investigaciones Cerebrales, Universidad Veracruzana, Xalapa, Ver., Mexico;1. Unidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C. (CIATEJ), Guadalajara, Mexico;2. Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico;3. Departamento de Fisiología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (UdeG), Jalisco, Mexico;4. Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo (UMSNH), Tarímbaro, Mexico;5. Instituto de Investigación en Ciencias Biomédicas (IICB), CUCS, UdeG, Jalisco, Mexico;6. Instituto de Investigaciones Biomédicas (IIB), UNAM, Mexico City, Mexico;7. Departamento de Investigación y Desarrollo, Laboratorios Virbac América Latina, Guadalajara, Jalisco, Mexico |
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| Abstract: | The present study aimed to characterize the chlorogenic acid (ChlA) capacity to reverse the toxic effects induced by ochratoxin A (OTA) in a subacute toxicity test in rats. Male Wistar rats were fed orally by gavage for 28 days with OTA (0.4 mg/kg bw/day), ChlA (5 mg/kg bw/day) or the combination OTA (0.4 mg/kg bw/day) + ChlA (5 mg/kg bw/day). No deaths, no decrease in feed intake or body weight in any experimental group were recorded. The negative control group and the animals treated with ChlA alone showed no changes in any parameters evaluated. In OTA-treated group significant changes such as decrease in urine volume, proteinuria, occult blood, increase in serum creatinine values; decrease in absolute and relative kidney weight and characteristics histopathological lesions that indicated kidney damage were observed. However, limited effect on oxidative stress parameters were detected in kidneys of OTA-treated group. Animals treated with the combination OTA + ChlA were showed as negative control group in the evaluation of several parameters of toxicity. In conclusion, ChlA, at given concentration, improved biochemical parameters altered in urine and serum and pathological damages in kidneys induced by OTA exposure, showing a good protective activity, but not by an apparent antioxidant mechanism. |
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| Keywords: | Ochratoxin A Kidney damage Chlorogenic acid Oral treatment Protective effects Oxidative stress |
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