The effect of lead exposure on expression of SIRT1 in the rat hippocampus |
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| Affiliation: | 1. Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China;2. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, PR China;3. Department of Anatomy, School of Medicine, Nanchang University, BaYi Road 461, Nanchang 330006, PR China;4. Department of Medical Experiment Teaching, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China;1. Laboratory of Pharmacology, Chulabhorn Research Institute, Thailand;2. Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand;3. Center of Excellence on Environmental Health and Toxicology (EHT), Office of the Higher Education Commission, Thailand;1. Department of Cellular Signalling, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland;2. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland;3. Department of Physiology, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland;4. Department of Histology and Embryology, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland;5. Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460 Szczecin, Poland;6. Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warsaw, Poland;1. Dept of Public Health Sciences, University of Texas, El Paso, TX, United States;2. Border Biomedical Research Center, Toxicology Core, University of Texas, El Paso, TX, United States;3. Dept of Psychology, University of Texas, El Paso, TX, United States;4. Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, United States;1. School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China;2. Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, China;3. School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China;4. School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 330106, China |
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| Abstract: | ![]()
Based on how the silent information regulator 2 homolog 1 (SIRT1) regulates the cyclic AMP response element binding protein (CREB), which is the molecular switch of long-term memory that maintains cognitive function, it is postulated that the impact of lead (Pb) on SIRT1 is one of the mechanisms leading to Pb-induced cognitive and learning deficits. Hence, the purpose of this study was to investigate the effect of Pb exposure on the expression of SIRT1, and the reversion effect of resveratrol, which is an activator of SIRT1. We examined the effects of maternal rat ingestion of Pb in drinking water during gestation and lactation on the expression of SIRT1 and CREB in the hippocampus of their offspring at postnatal week 3 (PNW3) and 52 (PNW52), and then reexamined these effects in offspring after intragastric administration of resveratrol for 4 weeks. Pb exposure decreased SIRT1 and CREB phosphorylation in a dose-dependent manner in the rat hippocampus at both PNW3 and 52, and resveratrol reversed those losses. These results indicated that SIRT1 might be a novel target to prevent Pb neurotoxicity. |
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| Keywords: | Lead Silent information regulator 2 homolog 1 cAMP-response element binding protein Resveratrol Rat hippocampus |
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