90例2型糖尿病合并慢性并发症的骨代谢的变化

目的 探讨2型糖尿病合并慢性并发症骨代谢的改变和机制。方法 测定90例2型糖尿病合并慢性并发症及70例2型糖尿病无并发症患与年龄，体重指数相匹配100例健康对照组的骨密度，血清骨钙素（BGP），钙（Ga)，尿羟脯氨酸（HOP），空腹及餐后2h的血糖，糖化血红蛋白（HbAlc)等进行比较。结果 2型糖尿病合并慢性并发症组BMD明显下降，FBG，PBG，尿HOP均高于2型糖尿病无慢性并发症组，BMD与糖尿病的病程，FBG，PBG，尿HOP呈显的负相关。结论 2型糖尿病合并慢性并发症组，糖尿病病程长，血糖高，BMD下降，比2型糖尿病无慢性并发症患更易患骨质疏松，骨吸收大于骨形成，骨矿含量明显下降。

Changes of bone metabolism in 90 patients with type 2 diabetes mellitus with chronic compliations

Objective To investigate the changes and mechanisms of bone metabolism in diabetic patients with chronic complications. Methods Single energy X ray absorptiometry (SXA) was used to determine the BMD in 90 patients with type 2 diabetes mellitus(DM) Serum osteocalcin (BGP),calcium,phosphorum,alkaline phosphatase(ALP),urinary calcium,hydroxyprolin(Hop),fasting blood glucose (FBG),postprandial blood glucose(PBG) and hemoglobin Alc were measured,and were compared with those in age and BMI matched healthy control group( n =100), type 2 DM patients with out chronic complication (n =70) Results Compared with the control group,the BMD in diabetic patients with chronic complications was significantly decreased FBG, PBG and urinary hydroxyprolin(Hop) were all higher than those in the diabetic patients without complications The changes in BMD significantly negatively correlated with duration of disease,FBG,PBG and urinary hydroxyprolin(Hop) Conclusion Long duration of diabetic disease,elevated blood glucose, and decreased of BMD are obsewed in the type 2 DM patients with chronic complications Compared with control group,the diabetic patients with chronic complications are liable to osteoporosis The rate of bone resorption is significantly higher than that of bone formation, and bone mineral content is significantly decreased