子宫肌瘤中血管内皮生长因子及孕激素受体的表达

目的：研究血管内皮生长因子及孕激素受体在子宫肌瘤和正常子宫肌层中的表达及其在肌瘤发展中的作用。方法：应用免疫组织化学SP法检测40例子宫肌瘤组织和相应子宫肌层组织中血管内皮生长因子（VEGF）及孕激素受体（PR）表达。结果：子宫肌瘤血管内皮生长因子阳性率为77．5％，孕激素受体阳性率为87．5％，相应子宫肌层组织阳性率分别为12．5％、37．5％。两组间比较有显著性差异（P〈0．05），血管内皮生长因子及孕激素受体表达之间存在明显关联性（P〈0．01）。结论：子宫肌瘤的发生发展可能与血管内皮生长因子及孕激素受体有关。

Expression of vascular endothelial growth factor and progesterone receptor in human uterine leiomyoma

Objective：To study the role of vascular endothelial growth factor （VEGF） and progesterone receptor （PR） in human uterine leiomyoma, nethods：Immunohistochemical SP method was used to detect the expressions of vascular endothelial growth factor（VEGF） and progesterone receptor （PR） in 40 examples of uterine leiomyoma and their corresponding myometrium. Results ： The positive rates of the expressions of VEGF and PR in uterine leiomyoma were 77.5% and 87.5% , and those of their corresponding myometrium were 12.5% and 37.5% respectively. The expression of VEGF and PR in uterine leiomyoma was obviously stronger than that of its corresponding myometrium （P 〈 0. 05 ）. Moreover,there was a close correlation between VEGF and PR expression levels（ P 〈 0.01 ）. Conclusion： The genesis and development of hysteromyoma may be correlated with VEGF and PR.