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| 纳米碳酸钙/聚L-乳酸复合材料的力学性能及生物相容性研究 | |
| 引用本文： | 刘建国,徐执扬,李冬松,徐莘香. 纳米碳酸钙/聚L-乳酸复合材料的力学性能及生物相容性研究[J]. 生物医学工程学杂志, 2006, 23(4): 805-808 |
| 作者姓名： | 刘建国 徐执扬 李冬松 徐莘香 |
| 作者单位： | 吉林大学,第一临床医院,骨科,长春,130021 |
| 基金项目： | 教育部高校骨干教师资助计划;吉林省科技厅科技发展计划 |
| 摘 要： | 合成纳米碳酸钙／聚L-乳酸复合材料，并评价其生物相容性、力学性能。利用细胞培养技术将合成的纳米碳酸钙／聚L-乳酸复合材料与细胞标准株体外共培养．动态观察细胞生长情况；对材料进行初始强度的力学测试。力学测试显示纳米碳酸钙／聚L-乳酸复合材料具有较高的初始强度．同时材料具有良好的生物相容性。纳米碳酸钙与聚L-乳酸复合后，提高了其力学性能．并使材料具有一定的生物活性。 |
| 关 键 词： | 纳米碳酸钙 聚L-乳酸 生物降解材料 |
| 收稿时间： | 2004-12-28 |
| 修稿时间： | 2004-12-282005-07-12 |
Mechanical Properties and Biocompatibility of Nanometer Calcium Carbonate/Poly (L-lactide) Composites |
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| Liu Jianguo,Xu Zhiyang,Li Dongsong,Xu Shenxiang. Mechanical Properties and Biocompatibility of Nanometer Calcium Carbonate/Poly (L-lactide) Composites[J]. Journal of biomedical engineering, 2006, 23(4): 805-808 | |
| Authors: | Liu Jianguo Xu Zhiyang Li Dongsong Xu Shenxiang |
| Affiliation: | Department of Orthopaedics, The First Hospital of Jilin University, Changchun 130021,China |
| Abstract: | The purpose of this study is to synthesize nanometer calcium carbonate/ poly(L-lactide) composites and evaluate its biocompatibility,and mechanical properties.The nanometer calcium carbonate/ poly(L-lactide) composites was prepared by the method of solution mixing and cell culture.Its properties were analyzed using,mechanical tests,MTT assay,transmission electron microscope and scanning electron microscope.It was found that the new kind copolymer had good biocompatibility,nanometer calcium carbonate could enhance the strength of the pure poly(L-lactide) matrix.The nanometer calcium carbonate/ poly(L-lactide) composites is a promising bioabsorbable material.It is worth further medical research. |
| Keywords: | Nanometer calcium(Nano-CaCO_3) Carbonate/poly(L-lactide) Biodegradable material |
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