|
|||||
|
|
| SCN5A基因突变与青壮年猝死综合征 | |
| 引用本文： | 周峰,成建定. SCN5A基因突变与青壮年猝死综合征[J]. 国外医学:内科学分册, 2007, 34(9): 556-558 |
| 作者姓名： | 周峰 成建定 |
| 作者单位： | 中山大学中山医学院法医病理学教研室,广东,广州,510080;中山大学中山医学院法医病理学教研室,广东,广州,510080 |
| 摘 要： | 青壮年猝死综合征(SUNDS)的病因迄今不明。随着分子遗传学和心脏离子通道研究的深入,SCN5A基因突变已被确定为Brugada综合征、3型长QT间期综合征的最重要病因。本文综述文献,结合项目组研究,介绍SCN5A基因突变与SUNDS发生的相关性。 |
| 关 键 词： | 青壮年猝死综合征 SCN5A 基因突变 |
| 文章编号： | 1004-2369（2007）09-0556-03 |
| 修稿时间： | 2007-04-16 |
The relationship between SCN5A gene mutation and the occurrence of sudden unexplained nocturnal death syndrome |
|
| ZHOU Feng,CHENG Jian-ding. The relationship between SCN5A gene mutation and the occurrence of sudden unexplained nocturnal death syndrome[J]. Foreign Medical Sciences(Section of Internal Medicine), 2007, 34(9): 556-558 | |
| Authors: | ZHOU Feng CHENG Jian-ding |
| Affiliation: | Department of Forensic Pathology, Zhongshan Medical School, Sun Yat-sen University, Guangzhou 510080, China |
| Abstract: | The etiology of sudden unexplained nocturnal death syndrome(SUNDS)is so far unknown.With the deep research on molecular genetics and cardiac ion channel,The SCN5A mutation was confirmed to be the most important cause of Brugada syndrome and Type 3 Long QT interval syndrome.According to our epidemiologic data and literatures,the relationship between SCN5A gene mutation and the occurrence of SUNDS were illuminated in the text. |
| Keywords: | Sudden unexplained nocturnal death syndrome SCN5A Gene mutation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |