细胞周期调控和骨肉瘤的发生发展

骨肉瘤是一类细胞周期性疾病,其发生发展与细胞周期有关。细胞周期的正常运行依赖于许多调节因子，如细胞周期素依赖激酶(CDKs)、细胞周期素(cyclins)、细胞周期素依赖激酶抑制蛋白(CKIs)等的相互作用，通过各调节因子保持动态平衡来保证细胞周期的正常循环，若其中任一类调节因子过多或过少，非正常激活、灭活等都将破坏细胞周期的正常进行，从而异常细胞可逃离正常监测，形成独立的细胞周期，发生骨肉瘤。

The relation of cell cyclecontrol and the development of osteosarcoma

Osteosarcoma is a kind of disease relative to cell cycle.The normal cell cycle depends on many control factors,such as CDKs,Cyclins,CKIs,et al.So as to keep the normal cell cycle revolving,everyone of the control factors must be dynamic equilibrium,ortherwise,the cell cycle would be destroyed and the normal cells would deteriorate and develop to osteosarcoma.