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| 阿魏酸钠对肺心病急性加重肺动脉高压、血浆内皮素、D—二聚体的影响 | |
| 引用本文： | 王荣丽!646000,杨小琼!646000,王艳!646000,周贤梅,胡晓灵!646000. 阿魏酸钠对肺心病急性加重肺动脉高压、血浆内皮素、D—二聚体的影响[J]. 临床内科杂志, 2001, 18(5): 343-344 |
| 作者姓名： | 王荣丽!646000 杨小琼!646000 王艳!646000 周贤梅 胡晓灵!646000 |
| 作者单位： | 四川省泸州医学院附属医院(王荣丽!646000，杨小琼!646000，王艳!646000，胡晓灵!646000)，南京鼓楼医院(周贤梅) |
| 摘 要： | 目的 探讨阿魏酸钠 (川芎素 )在慢性肺心病急性加重期的治疗作用及其可能机制。方法 对 48例慢性肺心病急性加重期患者用阿魏酸钠静滴治疗 2周 ,测定其治疗前后平均肺动脉压(mPAP)、血浆内皮素 (ET) 1及D 二聚体水平。结果 阿魏酸钠治疗后患者mPAP由 ( 31 .2± 4.0 )mmHg降至 ( 2 5.4± 2 .2 )mmHg ,ET 1由 ( 1 .96± 0 .2 5)ng/L降至 ( 1 .6 2± 0 .36 )ng/L ,D 二聚体由( 6 .8± 0 .7)mg/L降至 ( 4.9± 0 .6 )mg/L。结论 阿魏酸钠可明显降低肺动脉压 ,其机制可能是保护血管内皮细胞及抗凝 ,减少血管活性物质的产生及肺小动脉血栓形成。 |
| 关 键 词： | 阿魏酸钠 肺心病 内皮素－1 D－二聚体 肺动脉高压 |
| 文章编号： | 1001-9057(2001)05-0343-02 |
| 修稿时间： | 2001-03-14 |
Effect of sodium ferulate on pulmonary artery pressure, plasma endothelin-1 and D-dimer in patients with chronic pulmonary heart disease |
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| WANG Rongli,YANG Xiaoqiong,WANG Yan,et al.. Effect of sodium ferulate on pulmonary artery pressure, plasma endothelin-1 and D-dimer in patients with chronic pulmonary heart disease[J]. Journal of Clinical Internal Medicine, 2001, 18(5): 343-344 | |
| Authors: | WANG Rongli YANG Xiaoqiong WANG Yan et al. |
| Affiliation: | WANG Rongli,YANG Xiaoqiong,WANG Yan,et al. Department of Internal Medicine,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China |
| Abstract: | Objective To investigate the therapeutic role of sodium ferulate in patients with chronic pulmonary heart disease,Methods 48 patients with chronic pulmonary heart disease received sodium ferulate for 2 weeks and the mean pulmonary artery pressure (mPAP), plasma endothelin(ET) 1 and D dimer levels were measured.Results After sodium ferulate treated, mPAP, plasma ET 1 and D dimer levels were significantly lower in patients with chronic pulmonary heart disease.Conclusions Sodium ferulate may significantly reduce mPAP by reducing ET 1 production and thrombi formation in small pulmonary arteries and arterioles. |
| Keywords: | Sodium ferulate Pulmonary heart disease ET 1 D dimer |
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