Subthalamic nucleus neurones in slices from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mice show irregular,dopamine-reversible firing pattern changes,but without synchronous activity |
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| Authors: | C.L. Wilson D. Cash K. Galley H. Chapman M.G. Lacey I.M. Stanford |
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| Affiliation: | 1. School of Life and Health Sciences, Biomedical Sciences, Aston University, Birmingham B4 7ET, UK;2. Division of Neuroscience, University of Birmingham, Birmingham B15 2TT, UK;3. Institute of Psychiatry, King’s College London, London SE5 8AF, UK;4. GlaxoSmithKline, Neurology and Gastrointestinal Centre of Excellence for Drug Discovery, Harlow, Essex CM19 5AW, UK |
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| Abstract: | The loss of dopamine in idiopathic or animal models of Parkinson’s disease induces synchronized low-frequency oscillatory burst-firing in subthalamic nucleus neurones. We sought to establish whether these firing patterns observed in vivo were preserved in slices taken from dopamine-depleted animals, thus establishing a role for the isolated subthalamic–globus pallidus complex in generating the pathological activity. |
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| Keywords: | basal ganglia in vitro single unit Parkinson&rsquo s disease dopamine MPTP |
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