猪脊髓轴向张力改变中脊髓周围血流变化的实验研究

目的　探索实验猪不同脊髓轴向张力条件下脊髓周围血流的变化。 方法　采用3头广西雄性白猪进行造模，应用术中超声测量猪脊髓原始状态、腰椎L3/4撑开5mm状态、L3/4短缩5mm状态下的脊髓横断面和矢状面的直径及脊髓M波振幅、脊髓周围血流的时间-强度曲线数据，并采用配对t检验进行数据比较。 结果　与猪脊髓原始状态相比，在撑开状态下猪脊髓被拉长，直径变小，脊髓搏动幅度降低，脊髓周围血流减慢，血流曲线上升幅度减缓，血流灌注量减少，差异均有统计学意义（P均＜0.05）。相反，与猪脊髓原始状态相比，在短缩状态下猪脊髓直径变大，搏动幅度增加，脊髓周围血流曲线上升幅度增快，血流灌注量增大，差异均有统计学意义（P均＜0.05）。 结论　猪脊髓张力变化与脊髓的搏动振幅和周围血流灌注量相关。

Changes of bloodstream around spinal cord during variation of axial tension of porcine spinal cord

ObjectiveTo explore the changes of bloodstream around spinal cord under different axial spinal cord tensions in experimental pigs.MethodsThree male Guangxi white pigs were used for modeling. Intraoperative ultrasound was used to measure the diameter of spinal cord cross section and sagittal plane, spinal cord M-wave amplitude and time-intensity curve of bloodstream around spinal cord in porcine spinal cord original state, lumbar intervertebral space L_3/4 distraction 5 mm state and lumbar intervertebral space L_3/4 shortening 5 mm state, and the data were compared by paired t test.ResultsCompared with those in the original state of porcine spinal cord, in the distraction state the porcine spinal cord diameter was significantly smaller, the pulsation amplitude was significantly decreased, the perispinal bloodstream was significantly slower, the rising amplitude was significantly decelerated, and the blood perfusion was significantly decreased (all P < 0.05). Compared with the original state, in the shortening state the diameter of the spinal cord was significantly larger, the pulsation amplitude was significantly increased, the rising amplitude of bloodstream curve around the spinal cord was significantly slower, and the blood perfusion was significantly decreased (all P < 0.05).ConclusionThe changes of porcine spinal cord tension are related to the pulsatile amplitude of spinal cord and perispinal blood perfusion.