Duration of cigarette smoking is a risk factor for oropharyngeal cancer mortality among Japanese men and women: the Ibaraki Prefectural Health Study (IPHS) |
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Authors: | Nobue Saito Toshimi Sairenchi Fujiko Irie Hiroyasu Iso Kyoko Iimura Hiroshi Watanabe Takashi Muto Hitoshi Ota |
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Affiliation: | 1. Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA;2. Sierra Leone Epidemiological Data Team, ICAP, Freetown, Sierra Leone;3. Concern Worldwide, Freetown, Sierra Leone;4. World Bank, Washington, DC;5. Ministry of Health and Sanitation, Freetown, Sierra Leone;6. African Field Epidemiology Network (AFENET), Freetown, Sierra Leone;7. Centers for Disease Control and Prevention, Freetown, Sierra Leone;8. The Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, Washington, DC |
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Abstract: | PurposeThe relationship between duration of cigarette smoking and the risk of oropharyngeal cancer has not been studied in the general Japanese population. Thus, the aim of the present study was to examine the relationship between the duration of cigarette smoking and the risk of oropharyngeal cancer mortality in the Japanese population.MethodsIn this large cohort study, 32,989 men and 63,894 women, ages 40–79 years, who completed health check-ups in Ibaraki Prefecture, Japan, in 1993 were followed through 2008. Oropharyngeal cancer mortality was identified by death certificates. Smoking habits were divided into five categories, and years of cigarette smoking and pack-year classifications were divided into four categories. Hazard ratios and 95% confidence intervals for oropharyngeal cancer mortality were calculated by use of the Cox proportional hazards regression models.ResultsDuring the follow-up period, deaths from oropharyngeal cancer occurred in 38 of 32,989 men and 31 of 63,894 women. The multivariate hazard ratios for oropharyngeal cancer mortality were significantly greater for those subjects currently smoking for 40 years or longer (hazard ratio: 4.22, 95% confidence interval: 1.23–14.51), and they were greater with longer years of cigarette smoking among men (P for trend = .027).ConclusionsSmoking duration can be a risk factor for oropharyngeal cancer mortality in the Japanese population. |
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Keywords: | Cohort studies Oropharyngeal neoplasms Risk factors Smoking |
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