| 纤溶酶原激活物抑制物1和器官纤维化 |
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| 引用本文： | 王文革,王俭勤. 纤溶酶原激活物抑制物1和器官纤维化[J]. 医学综述, 2010, 16(9) |
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| 作者姓名： | 王文革 王俭勤 |
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| 作者单位： | 兰州大学第二医院肾病科,兰州,730030 |
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| 摘 要： | 近年来器官纤维化机制的研究热点集中在细胞外基质(ECM)降解过程及其发生机制上。纤溶酶原激活物及其抑制物1(PAI-1)是参与调节ECM代谢的关键酶系,PAI-1的异常表达在器官纤维化的进展过程中起重要作用。现对PAl-1生物学特性以及它和肾纤维化、肺纤维化、肝纤维化、心脏纤维化的关系的研究进展予以综述,为器官纤维化的诊治提供参考。
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| 关 键 词： | 纤溶酶原激活物抑制物1 转化生长因子 纤维化 |
Plasminogen Activator Inhibitor-1 and Organic Fibrosis |
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| WANG Wen-ge,WANG Jian-qin. Plasminogen Activator Inhibitor-1 and Organic Fibrosis[J]. Medical Recapitulate, 2010, 16(9) |
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| Authors: | WANG Wen-ge WANG Jian-qin |
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| Abstract: | At present the research on organic fibrosis mainly focuses on the degradation of extracellular matrix and its mechanisms.The system of plasminogen activator and plasminogen activator inhibitor-1 is a key enzyme system involved in adjusting the metabolism of extracellular matrix.The abnormal expression of PAI-1 plays an important role in organic fibrosis.In this review,the characteristics of PAI-1 and the association with organic fibrosis,such as renal fibrosis,pulmonary fibrosis,hepatic fibrosis and cardiac fibrosis were summarized to direct the diagnosis and therapy of organic fibrosis. |
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| Keywords: | Plasminogen activator inhibitor-1 Transforming growth factor Fibrosis |
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