| 加压素在针刺镇痛中的作用及其与中枢单胺类神经递质和脑啡肽含量变化的分析 |
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| 引用本文： | 刘琦,韩苇,赵建础.加压素在针刺镇痛中的作用及其与中枢单胺类神经递质和脑啡肽含量变化的分析[J].针刺研究,1988(3). |
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| 作者姓名： | 刘琦 韩苇 赵建础 |
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| 作者单位： | 陕西省中医药研究院中医基础理论研究二室，陕西省中医药研究院中医基础理论研究二室，陕西省中医药研究院中医基础理论研究二室 |
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| 摘 要： | <正> 鉴于不少文献报导在针刺镇痛中有阿片肽及中枢单胺类递质参与,联系我们以往在实验中曾看到的电针后脑脊液中加压素含量增加。以及近年来发现加压在脑内有镇痛作用。这种镇痛作用不被阿片受体阻断剂NX 所拮抗。本文拟观察在精—加压素(AVP)镇痛效应中亮—脑腓肽(LEK)与单胺类递质的变化以及和电针镇痛的关系。
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THE EFFECT OF VASOPRESSIN IN ACUPUNCTURE ANALGESIUA |
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| Abstract: | Arg-Vasopressin (AVP)has obvious analgesic effect.This effect is not
depressed by nalxone (NX),an antagonist of opiate receptor.It was observed that concentration of Leu-enkephalin (LEK) was decreased and catecholamines
(CAS) were elevated in brain by injection of AVP (icv) or by electroacu-
puncture (EA).This (?)ndicates that both treatments can influence the metabo-
lism of the LEK and CAs.Naloxone can turn the analgesic effect of EA,but
can not brock the effect of AVP.The effect of AVP seems to be through
the descending inhibitory system or through the subtype of opiate receptor.
The analgesic effect of EA is more complicated,besides opioid peptides,some
non-opioid peptides may also be involved. |
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