| 造血干细胞移植治疗恶性血液病疗效分析 |
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| 引用本文： | 刘启发,张钰,魏永强,徐丹,孙竞,徐兵,刘晓力,冯茹,孟凡义,周淑芸. 造血干细胞移植治疗恶性血液病疗效分析[J]. 肿瘤防治研究, 2004, 31(6): 356-358 |
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| 作者姓名： | 刘启发 张钰 魏永强 徐丹 孙竞 徐兵 刘晓力 冯茹 孟凡义 周淑芸 |
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| 作者单位： | 510515,广州,第一军医大学南方医院血液科 |
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| 基金项目： | 国家自然科学基金，广东省社会发展科技攻关项目 |
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| 摘 要： | 目的 比较自体与异体造血干细胞移植 (HSCT)治疗白血病和非霍杰金氏淋巴瘤 (NHL)的疗效和移植相关死亡。方法 2 2 2例白血病和NHL中 ,112例接受自体HSCT、110例接受异体HSCT ,其中38例急性早幼粒细胞白血病 (M3 )和 36例NHL均为自体HSCT。移植预处理方案包括 :14 9例TBI +Cy、2 3例改良Bucy、5 0例MACC方案。 结果 全部患者均获得造血重建 ,在自体与异体移植后白细胞>1.0× 10 9/L和血小板 >2 0× 10 9/L的时间 ,二组分别为 (14 .3± 6 .1)d和 (17.8± 9.2 )d与 (15 .1±4 .6 )d和 (19.6± 10 .3)d ,二组比较造血重建时间无差异 (P >0 .0 1)。非M3 白血病自体与异体移植后 5年估计无病生存率为 (5 2 .0± 5 .8) %和 (6 2 .4± 6 .2 ) %、复发率为 (44 .7%和 14 .5 % ) ,M3 白血病自体移植无病生存率 (93.6± 4 .4 ) %、复发率 5 .3% ,NHL自体移植无病生存率 (6 6 .3± 8.0 ) %、复发率 2 2...
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| 关 键 词： | 造血干细胞移植 自体和异体 恶性血液病 疗效 并发症 |
| 文章编号： | 1000-8578(2004)06-0356-03 |
| 收稿时间： | 2004-02-17; |
The Effect''''s Analysis of Hematopoietic Stem Cell Transplantation(HSCT) for Hematological Malignancies |
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| LIU Qi fa,ZHANG Yu,WEI Yong qiang,XU Dan,SUN Jing,XU Bing,LIU Xiao li,FENG Ru,MENG Fan yi,ZHOU Shu yunDept. of Hematology,NanFang Hospital,First Military Medical University,GuangZhou ,China. The Effect''''s Analysis of Hematopoietic Stem Cell Transplantation(HSCT) for Hematological Malignancies[J]. Cancer Research on Prevention and Treatment, 2004, 31(6): 356-358 |
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| Authors: | LIU Qi fa ZHANG Yu WEI Yong qiang XU Dan SUN Jing XU Bing LIU Xiao li FENG Ru MENG Fan yi ZHOU Shu yunDept. of Hematology NanFang Hospital First Military Medical University GuangZhou China |
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| Affiliation: | LIU Qi fa,ZHANG Yu,WEI Yong qiang,XU Dan,SUN Jing,XU Bing,LIU Xiao li,FENG Ru,MENG Fan yi,ZHOU Shu yunDept. of Hematology,NanFang Hospital,First Military Medical University,GuangZhou 510515,China |
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| Abstract: | Objective To investigate the effects and Transplant related mortality(TRM) of autologous (auto ) and allogeneic(allo ) hematopoietic stem cell transplantation(HSCT) for leukemia and Non Hodgkin s lymphoma (NHL).Methods 222 patients with leukemia and NHL, 112 patients were treated with auto HSCT and 110 with allo HSCT. All patients of 38 acute promyelocytic leukemia (APL) and 36 patients NHL were treated with auto HSCT.149 cases were received TBI (total body irradiation)+CY (CTX), 23 cases modifie... |
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| Keywords: | Hematopoietic stem cell transplantation Autologous and allogeneic Hematological malignancies Eeffect complication |
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