体外反搏对冠心病患者脂质过氧化物及血脂的影响研究

本文研究观察了体外反搏(ECP)对冠心病(CHD)患者血浆脂质过氧化物(LPO),红细胞内超氧化物岐化酶(SOD)和血脂五项:胆固醇(TC),甘油三酯(TG),高密度脂蛋白(HDL—C),低密度脂蛋白(HDL—C),极低密度脂蛋白(VLDL—C)的影响。结果表明CHD患者红细胞SOD无变化,血浆LPO显著增高(P<0.005),血清TG及VLDL—C水平增高(P<0.01);与5％葡萄糖加丹参静滴对照,ECP可显著降低LPO、TC、TG及LDL—C水平,但不伴有SOD明显变化。提示:ECP是保护缺血心肌的有效抗氧化手段之一。

EFFECTS OF EXTERNAL COUNTERPULSATION ON LIPOPEROXIDE, BLOOD-LIPIDS AND LIPOPROTEINS OF PATIENTS WITH CORONARY HEART DISEASE

It was studied the effects of the external counterpulsation (ECP) on the plasmic lipoperoxide (LPO) .erythrocyte superoxide dismutase (SOD) , blood lipids and lipoproteins (including TC,TG.HDL-C and VLDL-c) of the patients with the coronary heart disease. All patients were divided into two groups - the treatmental group (n=12) and control group (n=10). The treatmental group was treated with ECP and control group was injected with 5% glucose plus injection Salvia miti- Orrhiza composite. Another 10 normal subjects were taken as the normal group. The results showed that compared with the normal group,the levels of SOD of the treatmental group was similar,the ones of LPO, TG and VLDL -c were higher(P<0. 05). Compared with the control group,ECP reduced significantly the levels of LPO, TC, TG and LDL-c and had not any effect on SOD. These findings suggest that ECP be an effective technique to protect cardiac muscles from the injury induced by oxygen free radicals.