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| NHE1抑制剂对缺血及再灌流心肌的保护作用 | |
| 引用本文： | 陈长勋,金若敏. NHE1抑制剂对缺血及再灌流心肌的保护作用[J]. 中国药理学通报, 2001, 17(5): 489-492 |
| 作者姓名： | 陈长勋 金若敏 |
| 作者单位： | 上海中医药大学药理学教研室 |
| 摘 要： | 心肌缺血时 ,由于细胞内 pH值下降 ,激活了Na+/H+交换泵 (NHE) ,细胞内Na+浓度升高 ,促进Na+ Ca2 +交换 ,最终导致细胞内Ca2 +超负荷 ,造成细胞损伤。NHE1抑制剂可通过抑制Na+/H+交换 ,防止细胞内Ca2 +超负荷及其他相关作用 ,对缺血再灌注心脏起保护作用 ,改善心肌功能。目前部分NHE1抑制剂已进行临床研究。 |
| 关 键 词： | Na+-H+交换抑制剂 心脏 缺血 再灌流 |
| 文章编号： | 1001-1978(2001)05-0489-04 |
Protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibitor |
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| CHEN Chang Xun,JIN Ruo Min. Protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibitor[J]. Chinese Pharmacological Bulletin, 2001, 17(5): 489-492 | |
| Authors: | CHEN Chang Xun JIN Ruo Min |
| Abstract: | During ischemia, the intracellular acidosis stimulates the Na /H exchanger. The increase in intracellular sodium secondary to increased Na /H exchange is reversed through exchange for calcium, resulting in calcium overload of the cells and producing cell injury and necrosis. NHE1 inhibitors exert a protective effect on myocardium subject to ischemia and reperfusion via reduction of Na /H exchange, attenuation of intracellular calcium accumulation and other mechanisms. |
| Keywords: | Na H exchange inhibitor heart ischemia reperfusion |
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