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| 颞叶癫痫患者颞叶皮层和海马组织内多药耐药相关蛋白1和胶质原纤维酸性蛋白共表达 | |
| 引用本文： | 杨志军,王春枝,王娆,卢洪流,徐如祥,李安民,梁树立.颞叶癫痫患者颞叶皮层和海马组织内多药耐药相关蛋白1和胶质原纤维酸性蛋白共表达[J].基础医学与临床,2009,29(8):801-805. |
| 作者姓名： | 杨志军 王春枝 王娆 卢洪流 徐如祥 李安民 梁树立 |
| 作者单位： | 1. 解放军北京军Ⅸ总仄院神经外科 100700 2. 解放军北京军区总医院附属八一儿童医院,北京,100700 3. 南方医科大学 珠江医院神经外科,广东 广州,510282 4. 解放军总医院附属第一医院 神经外科,北京,100853 |
| 摘 要： | 目的 观察颞叶癫痫病人多耐药基因1（MDR1）、胶质原纤维酸性蛋白（GFAP）和神经元特异性烯醇化酶（NSE）在颞叶和海马组织内的表达。方法 癫痫组样本来自12例颞叶癫痫病例的手术切除标本，对照组为4例非癫痫病的尸检脑组织。应用双重免疫荧光组织化学方法结合激光共聚焦显微镜技术显示MDR1、GFAP和NSE在颞叶和海马组织内的表达。结果 对照组颞叶皮质和海马齿状回内均可见到许多GFAP表达阳性的星形胶质细胞和NSE表达阳性的神经元，未见到表达MDR1的细胞。癫痫组颞叶皮质和海马齿状回内GFAP阳性星形胶质细胞高于对照组。颞叶皮层和海马组织内可见星形胶质细胞MDR1 和GFAP 共表达现象。结论 颞叶难治性癫痫可能与星形胶质细胞的多药耐药性有关。 |
| 关 键 词： | 颞叶癫痫 海马 多药耐药基因蛋白 胶质原纤维酸性蛋白 |
| 收稿时间： | 2008-6-17 |
| 修稿时间： | 2008-10-23 |
Co-expression of multiple drug resistance gene protein 1 and glial fibrillary acidic protein in patients with temporal lobe epilepsy in temporal lobe and hippocampus |
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| YANG Zhi-jun,WANG Chun-zhi,WANG Rao,LU Hong-liu,XU Ru-xiang,LI An-min,LIANG Shu-li.Co-expression of multiple drug resistance gene protein 1 and glial fibrillary acidic protein in patients with temporal lobe epilepsy in temporal lobe and hippocampus[J].Basic Medical Sciences and Clinics,2009,29(8):801-805. | |
| Authors: | YANG Zhi-jun WANG Chun-zhi WANG Rao LU Hong-liu XU Ru-xiang LI An-min LIANG Shu-li |
| Institution: | YANG Zhi-jun1,WANG Chun-zhi1,WANG Rao2,LU Hong-liu1,XU Ru-xiang2,LI An-min3,LIANG Shu-li3(1. BaYi Children's Hospital,General Hospital of Beijing Military District of Chinese PLA,Beijing 100700,2.Department ofNeurosurgery,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,3.Department of Neurosurgery,the FirstAffiliated Hospital of General Hospital of Chinese PLA,Beijing 100853,China) |
| Abstract: | Objective To detect the expression of multiple drug resistance gene protein 1(MDR-1),neuron-specific endase (NSE),and glial fibrillary acidic protein (GFAP) in the temporal lobe and hippocampal dentate gyrus of patients with temporal lobe epilepsy.Methods In epileptic group,the brain tissues including dentate gyrus and temporal lobe were obtained from 12 patients by operation with temporal lobe epilepsy. In control group,the brain tissues were obtained from 4 dead cases. By means of anti-MDR1 and GFAP or NS... |
| Keywords: | temporal lobe epilepsy hippocampus multiple drug resistance gene protein glial fibrillary acidic protein |
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