趋化因子及其受体参与癌痛的研究进展

<正>癌痛是指由于肿瘤压迫神经或者肿瘤直接侵犯组织导致的疼痛，这严重降低了癌症患者的生活质量。大多数癌痛是慢性的，病程3个月以上，疼痛程度通常与肿瘤生长或诊疗情况密切联系。癌痛可以分成伤害感受性疼痛及神经病理性疼痛，前者又区分为躯体痛及内脏痛；后者表现为持续出现痛觉过敏症状，这与外周或中枢神经发生病变有关。目前，关于癌痛的诊治尚缺乏有成效的具体方案。近年报告观察到，乳腺癌患者的外周血中CC趋化因子配体2(C-C motif chemokine ligand 2,CCL2)、CCL20、CXC趋化因子配体13(C-X-C motif chemokine ligand 13,CXCL13)等明显升高；在骨癌痛小鼠，

Research progress of chemokines and their receptors in cancer pain

Chemokines bind to its G-protein-coupled receptors on target cells inducing adjacent responding cells to produce directional chemotaxis. Interaction of chemokines and their receptors in dorsal root ganglion neurons,spinal dorsal horn and brain participates in the generation and maintenance of cancer pain in response to noxious stimuli.Chemokines have been suggested as candidates of cancer pain treatment. This article reviews the research progress of chemokines and their receptors involved in cancer pain.