北京城镇职工2型糖尿病患者缺血性脑卒中发病率及主要危险因素

目的: 通过对新发2型糖尿病患者进行前瞻性观察,探究2型糖尿病发病后缺血性脑卒中的发病特点,并进一步分析2型糖尿病患者缺血性脑卒中发病的危险因素。方法: 数据资料来源于北京市城镇职工基本医疗保险信息系统数据库。研究采用前瞻性设计,对2010年新诊断为2型糖尿病的患者在2010—2017年缺血性脑卒中的发病情况进行描述,采用Logistic回归模型分析2型糖尿病患者缺血性脑卒中发病的危险因素。结果: 共纳入185 813例新发2型糖尿病患者,平均年龄(58.5±13.2)岁,男性占49.0%。随访7年内出现新发缺血性脑卒中患者10 393例,累积发病率为5.6%,发病密度为8.1/1 000人年。2型糖尿病患者缺血性脑卒中在各个年龄段均有发生,不同年龄组累积发病率分别为:≤44岁组1.5%(95%CI:1.3%~1.6%),45~54岁组3.6%(95%CI:3.4%~3.7%),55~64岁组5.4%(95%CI:5.2%~5.5%),≥65岁组9.2%(95%CI:9.0%~9.4%),累积发病率随年龄升高而增加(P<0.05)。男性累积发病率(6.8%,95%CI: 6.7%~7.0%)高于女性(4.4%,95%CI: 4.3%~4.6%);<80岁的患者中,男性在各年龄段累积发病率均高于女性;≥80岁的患者中,女性累积发病率(9.2%)高于男性(7.9%)。进一步分析2型糖尿病患者缺血性脑卒中发病的危险因素,发现患有冠心病(OR=3.18,95%CI:2.72~3.72)、心力衰竭(OR=1.53,95%CI:1.32~1.79)、肾衰竭(OR=1.45, 95%CI:1.20~1.75)等合并症与2型糖尿病患者缺血性脑卒中的发病有关。结论: 2型糖尿病患者缺血性脑卒中发病率仍处于较高水平,应针对老年患者加强危险因素管理,尽早筛查2型糖尿病患者的合并症情况并采取针对性的预防控制措施。

Incidence and risk factors of ischemic stroke in patients with type 2 diabetes among urban workers in Beijing,China

Objective: To explore the incidence of ischemic stroke after the onset of type 2 diabetes, and further analyze the risk factors, so as to provide a basis for further research. Methods: The data were obtained from the database of the Beijing Urban Employee Basic Medical Insurance Database. The study used a prospective design to describe the incidence of ischemic stroke in patients with type 2 diabetes. In our study, these patients were followed up for seven years. Multivariate Logistic regression models were used to analyze the risk factors of ischemic stroke in patients with type 2 diabetes. Results: A total of 185 813 newly diagnosed type 2 diabetes patients were enrolled, with an average age of (58.5±13.2) years, and 49.0% of them were males. A total of 10 393 patients with newly diagnosed ischemic stroke occurred in 7 years, with a cumulative incidence of 5.6% and an incidence density of 8.1/1 000 person-years. Ischemic stroke occurred in all age groups in patients with type 2 diabetes. The cumulative incidence was 1.5% (95%CI: 1.3%-1.6%) in group ≤44 years old, 3.6% (95%CI: 3.4%-3.7%) in group 45-54 years old, 5.4% (95%CI: 5.2%-5.5%) in group 55-64 years old, and 9.2% (95%CI: 9.0%-9.4%) in group ≥65 years old, and the cumulative incidence increased with age (P<0.05). Cumulative incidence rate of the males (6.8%, 95%CI: 6.7%-7.0%) was higher than the females (4.4%, 95%CI: 4.3%-4.6%). Among the patients <80 years old, the cumulative incidence rate of the males was higher than that of the females in all the age groups. In the patients ≥80 years of age, the cumulative incidence was higher in the females (9.2%) than in the males (7.9%). Further analysis revealed that complications, such as coronary heart disease (OR=3.18, 95%CI: 2.72-3.72), heart failure (OR=1.53, 95%CI: 1.32-1.79) and kidney failure (OR=1.45, 95%CI: 1.20-1.75) were associated with ischemic stroke in the patients with type 2 diabetes. Conclusion: The incidence level of ischemic stroke in patients with type 2 diabetes is high. It is necessary to strengthen the management of risk factors in elderly patients, screen the complications of type 2 diabetes as early as possible, and take active preventive and control measures.