北五味子在胸主动脉瘤发生发展中作用机制的网络药理学和分子对接技术分析

目的:探讨北五味子(SCF)在胸主动脉瘤(TAA)发生发展过程中的作用,并阐明其可能的机制.方法:整合中药系统药理学数据库与分析平台(TCMSP)、Uniprot、Swiss TargetPrediction、CTD、GeneCards、OpenTargets和OMIM多个数据库获取SCF作用于TAA的潜在靶点;利用S...

Network pharmacology and molecular docking analysis on mechanism of Schisandrae Chinensis Fructus in occurrence and development of thoracic aortic aneurysm

To investigate the effect of Schisandrae Chinensis Fructus（SCF）in the occurrence and development of thoracic aortic aneurysm（TAA）， and to clarify its possible mechanism. Methords：The informations from multiple databases of Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（TCMSP），Uniprot， Swiss TargetPrediction，CTD，GeneCards， OpenTargets， and OMIM were integrated to obtain the potential targets for the treatment of TAA by SCF； the protein-protein interaction （PPI） network was constructed by String database and Cytoscape software， and the key targets of SCF acted on TAA were selected by topological analysis； Omicshare online analysis platform was used to conduct GO and KEGG enrichment analysis on the potential targets； the gene expression profile of rat smooth muscle cells stimulated by Schisandra chinese（turcz.） baill （SchB）， the main active ingredients of SCF was obtained from GEO database to verify the expression levels of core targets； Autodock software was used for molecular docking validation of key targets.