β受体阻滞剂在心力衰竭治疗中的应用

目的 介绍β受体阻滞剂治疗充血性心力衰竭(CHF)的病理生理、作用机制、应用指征和注意事项。方法 通过查阅国内外相关文献，综述对CHF的治疗应干预神经内分泌、减轻儿茶酚胺类对心肌的直接损害，从而明确β受体阻滞剂对CHF的治疗作用。结果 在标准化治疗的基础上合理使用β受体阻滞剂对Ⅱ～Ⅲ级(按NYHA分级)心力衰竭病人疗效确切。结论 稳定的轻、中度心力衰竭，NHYA分级Ⅱ～Ⅳ级病人，标准治疗加用β受体阻滞剂，可明显改善病人预后及降低死亡率，提高生活质量。

Application of beta-receptor blockade in congestive heart failure

OBJECTIVE To Introduce the mechanism, pathologic physiology, indication and precaution of applying beta-receptor blockade in congestive heart failure (CHF). METHODS We referred to domestic and international literatures to define the therapeutic function of beta-receptor blockade in CHF. RESULTS On the foundation of standardized treatment, reasonable use of beta-receptor blockade in grade II and III CHF (NYHA grade) was effective. CONCLUSIONS In the patient with stable, mild to moderate CHF, standardized treatment together with beta-receptor blockade can greatly improve the prognosis, lower the death ratio, and increase the life quality.