奥美拉唑联合法莫替丁治疗反流性食管炎疗效分析

目的:观察奥美拉唑联合法莫替丁治疗反流性食管炎的疗效.方法:将126例反流性食管炎患者随机分为联合用药组(奥美拉唑联合法莫替丁)、奥美拉唑组和法莫替丁组,每组各42例.联合用药组治疗方案为奥美拉唑20mg早餐前口服,法莫替丁20mg睡前口服;奥美拉唑组治疗方案为奥美拉唑20mg,每日2次;法莫替丁组治疗方案为法莫替丁20mg,每日2次.3组疗程均为8周.通过对烧心、反酸、胸痛等主要症状的改善进行评分及内镜下观察病变的改善情况评价临床疗效.结果:8周疗程结束后,联合用药组临床症状缓解情况和内镜下病变改善情况均较奥美拉唑组或法莫替丁组显著(P＜0.05).结论:奥美拉唑联合法莫替丁可有效抑制胃酸分

Observation of Clinical Curative Effect on Omeprazole Combining with Famotidine in Patients with Reflux Esophagitis

Objective:To observe the clinical curative effect of omeprazole combining with famotidine in patients with reflux esophagitis.Methods:126 patients with reflux esophagitis were randomly divided into 3 groups.A group were administrated with 20 mg omeprazole oral use before breakfast and 20 mg famotidine oral use at bedtime.B group were administrated with 20 mg omeprazole oral use bid.C group were administrated with 20 mg famotidine oral use bid.Each group was treated for 8 weeks.The clinical curative effect was estimated by the improvement score of clinical symptom and by gastroscope.Results:After 8 weeks’ therapy,the improvement score of clinical symptom and the result of gastroscope of omeprazole combining with famotidine group were better than either the omeprazole group or the famotidine group(P<0.05).Conclusion:The secretion of gastric acid can be effectively restrained by omeprazole combining with famotidine,which has reliable curative effect on reflux esophagitis.