| Expression of MTA2 Gene in Ovarian Epithelial Cancer and Its Clinical Implication |
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| 引用本文： | 冀予心 张萍 卢运萍 马丁. Expression of MTA2 Gene in Ovarian Epithelial Cancer and Its Clinical Implication[J]. 华中科技大学学报(医学英德文版), 2006, 26(3): 359-362. DOI: 10.1007/BF02829576 |
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| 作者姓名： | 冀予心 张萍 卢运萍 马丁 |
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| 作者单位： | Medical Center of Cancer Molecular Biology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China，Medical Center of Cancer Molecular Biology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China，Medical Center of Cancer Molecular Biology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China，Medical Center of Cancer Molecular Biology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China |
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| 基金项目： | ThisprojectwassupportedbygrantsfromNationalNatu-ralSciencesFoundationofChina(No.30300331)andNa-tionalKeyBasicResearchProject(No.2002CB513107). |
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| 摘 要： | Most members of metastasis-associated geneshave been identified since1994.Alot of evidenceshowed that the expression of MTA1were elevatedin human metastatic breast cell lines and metastaticcancer tissues,such as breast,colorectal,gastric,and esophageal carcinomas.MTA2,which is ho-mologous to MTA1,is a component of the NuRDATP-dependent chromatin remodeling and histonedeacetylase complex.Specifically,MTA2modu-lates the enzymatic activity of the histone deacety-lase core complext[1].Altho…
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| 关 键 词： | 卵巢癌 临床 基因表达 免疫组织化学 |
| 收稿时间： | 2006-02-26 |
Expression of MTA2 gene in ovarian epithelial cancer and its clinical implication |
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| Ji Yuxin,Zhang Ping,Lu Yunping,Ma Ding. Expression of MTA2 gene in ovarian epithelial cancer and its clinical implication[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(3): 359-362. DOI: 10.1007/BF02829576 |
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| Authors: | Ji Yuxin Zhang Ping Lu Yunping Ma Ding |
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| Affiliation: | Medical Center of Cancer Molecular Biology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | In order to investigate the roles of MTA2 in the pathogenesis of ovarian epithelial cancer, the expression of MTA2 in 4 ovarian cell lines were detected by semi-quantitative RT-PCR and Western-blot assays. MTA2 expression in normal, borderline, benign and malignant epithelial ovarian tissues was immunohistochemically examined. The expression of MTA2 mRNA and protein was detected in all of 4 cell lines of ovarian epithelial cancer. The expression of MTA2 mRNA and protein was higher in strong migration cell lines than in weak migration ones. In borderline and malignant ovarian tissues tested, MTA2 staining was dramatically stronger than in normal and benign tissues (P<0.01). The expression levels in malignant ovarian tissues were significantly higher than that in borderline epithelial ovarian tissues (P<0.01). The expression of MTA2 was correlated with clinical stage, histopathological grade and lymph node metastasis. It was concluded that the high expression of MTA2 was associated with more aggressive behaviors of epithelial ovarian cancer. MTA2 provides a novel indicator of ovarian cancer. |
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| Keywords: | MTA2 ovarian cell lines ovarian tumor gene expression immunohistochemistry |
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