SBHL对小鼠免疫功能影响的实验研究

目的探讨澳洲茄胺盐酸盐（SBHL）对环磷酰胺（CTX）处理小鼠免疫功能的影响。方法 Balb/c小鼠用环磷酰胺造成免疫抑制模型,同时尾静脉注射SBHL7d,观察小鼠免疫器官重量,脾细胞特异性抗体的产生、血清凝集素滴度、溶血素CH50值、ConA刺激的小鼠脾淋巴细胞增殖和小鼠腹腔巨噬细胞吞噬功能及血清中肿瘤坏死因子α含量的变化。结果 SBHL（40 mg/kg）尾静脉注射7 d,小鼠胸腺、脾脏重量增加。ConA刺激的小鼠脾淋巴细胞增殖明显。小鼠腹腔巨噬细胞吞噬功能显著增强。给药组小鼠血凝素滴度、溶血素CH50值、TNF-α也高于对照组。结论 SBHL能明显的改善环磷酰胺抑制的小鼠免疫功能,这可能是澳洲茄胺盐酸盐抗肿瘤的另一作用机理。

The experimental investigation of Sdosodine Hydrochlorida on immune function in mice

Objective To explore the improving immune function of the Sdosodine Hydrochlorida(SBHL)in mice treated with cyclophosphamide(CTX).Methods Balb/c mice treated with CTX were administrated with SBHL(40 mg/kg) for 7 d.The weights of spleens and thymus of the mice,specific antibody formation of splenocytes,serum agglutinin titer and hemolysin CH50 in mice immunized with SRBC were assayed.The proliferation of mouse splenic lymphocytes actived with ConA were measured.The peritoneal macrophage phagocytosis in mice ...