急性脑梗死患者血浆肾上腺髓质素含量的变化及其与内皮素的相关性

目的:探讨脑梗死后血浆肾上腺髓质素含量的变化及其与内皮素的相互关系.方法:应用放射免疫分析法检测62例急性脑梗死患者血浆肾上腺髓质素和内皮素的含量,进行动态观察,同时与54例健康体检者血浆肾上腺髓质素和内皮素的含量进行对比分析.结果:急性期脑梗死患者血浆肾上腺髓质素和内皮素的含量均升高,与正常对照组相比,差异非常显著(P均＜0.01).肾上腺髓质素的含量与病情严重程度呈显著正相关(r=0.856,P＜0.01);与梗死体积呈显著正相关(r=0.753,P＜0.01);与内皮素含量呈显著正相关(r=0.761,P＜0.01).动态观察脑梗死后血浆肾上腺髓质素含量变化,发现其高峰值出现在梗死后3 d,至2周左右已明显下降,但与正常对照组相比仍有显著性差异(P＜0.01).结论:脑梗死后血浆肾上腺髓质素含量变化可有助于判断病情严重程度、梗死灶的体积大小及病情预后.

Changes of adrenomedullin and its relationship with endothelin in patients with acute cerebral infarction

Objective: To investigate the variation of plasma adrenomedullin and its clinical significance in patients with acute cerebral infarction. Methods: We measured the plasma concentration of adrenomedullin in 62 patients with acute cerebral infarction by using radioimmunoassay and observed sequentially. Meanwhile, the same indexes of 54 health subjects were as control. Results: The plasma concentration of adrenomedullin increased in patients with cerebral infarction at acute stage, compared with that of the normal control, the difference was very obvious (P<0.01). The concentration of plasma adrenomedullin was significant positively correlated with the degree of the seriousness of the disease (r=0.856, P<0.01). The plasma concentration of adrenomedullin was significant positively correlated with the volume of infarction (r=0.753, P<0.01). There was positive correlation between plasma levels of adrenomedullin and endothelin. After sequential observation, we found level of adrenomedullin reach the peak at the 3rd day after cerebral infarction and obviously decreased 2 weeks later. Compared with the control, there was significant difference (P<0.01). Conclusion: The variation of plasma concentration of adrenomedullin after cerebral infarction was useful to judge the degree of the disease, the size of infarction, and the prognosis.