影响肾癌患者预后的相关因素分析

目的探讨影响肾癌患者预后的相关因素，为提高肾癌患者预后提供依据。方法选择2003年4月。2007年1月我院收治的255例肾癌患者作为研究对象，所有患者均接受肾癌根治术治疗，在治疗结束后我们再对患者进行5年的随访。根据随访结束时患者存活与否，我们将上述研究对象分为存活组（n=176）与死亡组（n=79）。结果①单因素分析结果显示两组患者的年龄、性别、病理类型、肿瘤大小、TNM分期、肉瘤样变、临床症状程度、腔静脉瘤栓、淋巴结转移、远处转移、术后免疫治疗等因素相比差异有统计学意义（P〈0．05）。②非条件Logistic回归分析显示TNM分期、肉瘤样变、腔静脉瘤栓、淋巴结转移、远处转移是影响肾癌患者预后的独立危险因素（P〈O．05），术后免疫治疗是影响。肾癌患者预后的独立保护因素（P〈0．05）。结论应采取相应的干预措施以改善肾癌患者预后。

Analysis of prognostic factors in renal cell carcinoma

Objective To investigate the prognostic factors in renal cell carcinoma, and provide basis for improving prog- nosis. Methods A total of 255 cases of renal cell carcinoma who were admitted into our hospital from April 2003 to Jan- uary 2007 were selected as the objects of study, and all patients, who were followed up for 5 years after treatment, received radical nephreetomy. According to be alive or not at the end of the follow-up period, these patients were divided into sur- vival group （n = 176） and death group （n = 79）. Results （1） The univariate analysis found that there were significant differ- ences in the age, gender, pathological type, tumor size, TNM stage, sarcomatoid, degree of clinical symptoms, vena cava tu- mor thrombus, lymph node metastasis, distant metastasis and postoperative immunotherapy between the two groups （P 〈 0.05）. （2） The logistic regression analysis found that the TNM stage, sarcomatoid, vena cava tumor thrombus, lymph node metastasis and distant metastasis were independent risk factors for prognosis in patients with renal cell carcinoma （P 〈 0.05）, and the postoperative immunotherapy was an independent protective factor （P 〈 0.05）. Conclusion According to the analysis results, we should take effective measures to improve the prognosis for patients with renal cell carcinoma.