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| 羟基磷灰石／40％氧化锆与骨组织相容性和生物活性的体内研究 | |
| 引用本文： | 李锋,王春阳,陶树清,陶天遵,荣杰生,韩文波.羟基磷灰石／40％氧化锆与骨组织相容性和生物活性的体内研究[J].哈尔滨医药,2009,29(4):1-3. |
| 作者姓名： | 李锋 王春阳 陶树清 陶天遵 荣杰生 韩文波 |
| 作者单位： | 1. 哈尔滨医科大学附属第二医院,黑龙江,哈尔滨,150086 2. 黑龙江省齐齐哈尔市第一医院,黑龙江,齐齐哈尔,161005 3. 哈尔滨工业大学材料学院,黑龙江,哈尔滨,150001 |
| 摘 要： | 目的探讨羟基磷灰石／40％氧化锆（HA／40％ZrO2）骨植入后组织相容性和生物活性。方法30只家兔右侧股骨大转子植入HA／40％ZrO2，左侧植入HA为对照组，于术后1、2、4周处死动物通过光镜和手术前后1周白细胞计数（WBC）观察局部及全身炎症反应和骨／植入物界面情况。于术后4、8、16周时处死动物，通过光镜和扫描电镜分析，观察局部炎症反应及骨／植入物界面结合进行研究。结果①1、2、4周后植入物局部及全身均有轻微炎症反应，空隙随时间延长而逐渐减小，术后WBC较术前升高，有显著差异；于8、16周时局部及全身无明显炎症反应，骨与植入物结合紧密且无明显空隙，两组间无显著差异。②光镜下见1、2周少量炎症细胞浸润，4、8、16周无明显炎症细胞浸润；4周两组植入物与宿主骨间见骨缺损区，内充满新生类骨质；8周两种植入物与新生骨组织整合，新生骨组织成熟度升高。③扫描电镜下见新生骨成熟度随植入时间而升高。结论HA／40％ZrO2有良好的组织相容性和生物活性，具有广阔的临床应用前景。 |
| 关 键 词： | 羟基磷灰石 氧化锆 组织相容性 生物活性 骨组织 |
Study on the vivo biocompatibility between hydroxyapatite/40% zirconia composite and animal bone tissue |
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| LI Feng,WANG Chunyang,TAO Shuqing,TAO Tianzun,RONG Jiesheng,HAN Wenbo.Study on the vivo biocompatibility between hydroxyapatite/40% zirconia composite and animal bone tissue[J].harbin medical journal,2009,29(4):1-3. | |
| Authors: | LI Feng WANG Chunyang TAO Shuqing TAO Tianzun RONG Jiesheng HAN Wenbo |
| Institution: | LI Feng1,WANG Chunyang2,TAO Shuqing1,TAO Tianzun1,RONG Jiesheng1,HAN Wenbo3(1.The 2nd Affililiated Hospital of Harbin Medical University,HeiLongJiang Harbin 150086,China,2.The 1st Hospital of Qiqihar,HeiLongJiang Qiqihar 161005,3.Harbin Institute of Technology,HeiLongJiang Harbin 150001) |
| Abstract: | Objective To explore histocompatibility and bioactivity between hydroxyapatite /40% zirconia(HA/40%ZrO2)composite and bone tissue.Methods The amount of 30 rabbits'right greater trochanter of femur were implanted with HA/40%ZrO2,the left greater trochanters of femur were implanted with HA for control group.Rabbits were sacrificed on 1,2 and 4 weeks after operation and local and systemic inflammatory reaction and insert-bone interface integration were analyzed by light microscopy and WBC(one week before and a... |
| Keywords: | Hydroxyapatite(HA) Zirconia Histocompatibility Bioactivity Bone tissue |
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